抗 22F 型肺炎链球菌荚膜免疫可预防小鼠定植和流感病毒共感染模型中的细菌传播。
Anti-capsular immunity to Streptococcus pneumoniae serotype 22F prevents bacterial transmission in murine colonization and influenza virus co-infection models.
机构信息
Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.
Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.
出版信息
Vaccine. 2021 Jan 15;39(3):469-472. doi: 10.1016/j.vaccine.2020.11.075. Epub 2020 Dec 19.
Abstract
We evaluated the effectiveness of anti-22F serotype immunity in the prevention of Streptococcus pneumoniae (Spn) bacterial transmission during colonization and influenza virus co-infection. Mice were immunized with 22F formulation and later colonized with Spn or co-infected with Spn and influenza virus. The 22F antisera exhibited strong reactivity to 22F bacteria and promoted the opsonic uptake of Spn by the neutrophils. The 22F vaccination led to a significant reduction of bacterial densities in the nasopharynx and prevented bacterial transmission during colonization and co-infection. The transfer of 22F antisera to infant mice resulted in reduced bacterial transmission in colonization and co-infection models.
摘要
我们评估了抗 22F 血清型免疫在预防定植和流感病毒共感染期间肺炎链球菌（Spn）细菌传播中的有效性。小鼠用 22F 制剂免疫，随后用 Spn 定植或 Spn 和流感病毒共感染。22F 抗血清对 22F 细菌表现出强烈的反应性，并促进中性粒细胞对 Spn 的调理摄取。22F 疫苗接种可显著降低鼻咽部的细菌密度，并防止定植和共感染期间细菌传播。将 22F 抗血清转移到婴儿小鼠中可减少定植和共感染模型中的细菌传播。
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Front Microbiol. 2020 Feb 27;11:309. doi: 10.3389/fmicb.2020.00309. eCollection 2020.
2
Immunogenicity and protective efficacy of monovalent PCVs containing 22F and 33F polysaccharides in mouse models of colonization and co-infection.22F 和 33F 多糖单价 PCV 在定植和混合感染小鼠模型中的免疫原性和保护效力。
Vaccine. 2018 Sep 11;36(38):5701-5708. doi: 10.1016/j.vaccine.2018.08.017. Epub 2018 Aug 11.
3
Exploring the role of competition induced by non-vaccine serotypes for herd protection following pneumococcal vaccination.探讨肺炎球菌疫苗接种后，非疫苗血清型引起的竞争对群体保护作用的影响。
J R Soc Interface. 2017 Nov;14(136). doi: 10.1098/rsif.2017.0620.
4
Population genomic datasets describing the post-vaccine evolutionary epidemiology of Streptococcus pneumoniae.描述肺炎链球菌疫苗接种后进化流行病学的人群基因组数据集。
Sci Data. 2015 Oct 27;2:150058. doi: 10.1038/sdata.2015.58. eCollection 2015.
5
Surveillance of the impact of pneumococcal conjugate vaccines in developing countries.监测肺炎球菌结合疫苗在发展中国家的影响。
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6
The role of influenza in the severity and transmission of respiratory bacterial disease.流感在呼吸道细菌性疾病的严重程度和传播中的作用。
Lancet Respir Med. 2014 Sep;2(9):750-63. doi: 10.1016/S2213-2600(14)70131-6. Epub 2014 Aug 15.
7
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