The Molecular Neuropharmacology Lab, School of Optometry & Ophthalmology and the State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou Medical University, Wenzhou, PR China.
Department of Neurology, Massachusetts General Hospital, Boston, USA.
Parkinsonism Relat Disord. 2020 Nov;80 Suppl 1(Suppl 1):S45-S53. doi: 10.1016/j.parkreldis.2020.10.024. Epub 2020 Dec 19.
The adenosine A receptor is a major target of caffeine, the most widely used psychoactive substance worldwide. Large epidemiological studies have long shown caffeine consumption is a strong inverse predictor of Parkinson's disease (PD). In this review, we first examine the epidemiology of caffeine use vis-à-vis PD and follow this by looking at the evidence for adenosine A receptor antagonists as potential neuroprotective agents. There is a wealth of accumulating biological, epidemiological and clinical evidence to support the further investigation of selective adenosine A antagonists, as well as caffeine, as promising candidate therapeutics to fill the unmet need for disease modification of PD.
腺苷 A 受体是咖啡因的主要靶点，咖啡因是全球应用最广泛的精神活性物质。大量的流行病学研究长期表明，咖啡因的摄入与帕金森病（PD）呈强烈的反比关系。在这篇综述中，我们首先检查了咖啡因使用与 PD 的流行病学关系，然后研究了腺苷 A 受体拮抗剂作为潜在神经保护剂的证据。大量的生物学、流行病学和临床证据支持进一步研究选择性腺苷 A 拮抗剂以及咖啡因作为有前途的候选治疗药物，以满足 PD 疾病修饰的未满足需求。
