Chemistry Department, Faculty of Science, Benha University, Benha, Qaliobiya 13518, Egypt.
Org Lett. 2021 Feb 19;23(4):1153-1156. doi: 10.1021/acs.orglett.0c03394. Epub 2020 Dec 22.
The formation of an unprecedented 12-membered macrocyclic ketal through the long-range participation of a levulinoyl group across a glycosidic linkage was observed in glycosylation reactions. This finding indicated that stereodirecting participation is not limited to groups within the glycan ring being activated, thus broadening the scope of remote group participation in glycosylation.
在糖基化反应中观察到通过乙酰基跨越糖苷键的远程参与形成了前所未有的 12 元大环缩酮。这一发现表明立体定向参与不仅限于被激活的聚糖环内的基团,从而拓宽了远程基团参与糖基化的范围。