Rajgor Harshadkumar Dhirajlal, James Steven, Botchu Rajesh, Grainger Melvin, Czyz Marcin
Orthopaedics, Royal Orthopaedic Hospital, Birmingham, GBR.
Radiology, Royal Orthopaedic Hospital, Birmingham, GBR.
Cureus. 2020 Nov 17;12(11):e11526. doi: 10.7759/cureus.11526.
Giant cell tumour (GCT) of the spine is a benign aggressive tumour with high recurrence rates. Patients can be asymptomatic due to the slow growth rate and present with localized pain or neurological dysfunction. Current management strategies include intralesional curettage, total en-bloc resection (TER) and denosumab therapy. Treatment strategies can be particularly challenging in women of childbearing age who wish to conceive, as the risks of tumour recurrence need to be balanced against the fetal complications associated with adjuvant denosumab therapy. This case report discusses the management options and controversies for women of childbearing age with GCT of the thoracic spine. Clinicians need to be aware of the complications associated with TER and denosumab treatment when managing GCTs of the spine in young females.
脊柱巨细胞瘤（GCT）是一种具有高复发率的侵袭性良性肿瘤。由于生长速度缓慢，患者可能无症状，也可能表现为局部疼痛或神经功能障碍。目前的治疗策略包括病灶内刮除术、整块切除术（TER）和地诺单抗治疗。对于希望怀孕的育龄女性，治疗策略可能特别具有挑战性，因为需要在肿瘤复发风险与辅助地诺单抗治疗相关的胎儿并发症之间取得平衡。本病例报告讨论了育龄期胸椎GCT女性的治疗选择和争议。临床医生在处理年轻女性脊柱GCT时，需要了解与TER和地诺单抗治疗相关的并发症。
