Department of Dermatology, Necmettin Erbakan University Meram Medical Faculty, Konya, Turkey.
Clinic of Dermatology, Konya Ereğli State Hospital, Konya, Turkey.
J Cosmet Dermatol. 2021 Aug;20(8):2635-2639. doi: 10.1111/jocd.13905. Epub 2020 Dec 28.
Lichen planus (LP) is an idiopathic, chronic inflammatory disease. Chronic inflammatory diseases can cause metabolic complications. In the literature, data related to the relationship between lichen planus and metabolic syndrome (MS) are limited. We aimed to evaluate the relationship between MS and lichen planus with disease activity.
The patients diagnosed with lichen planus at the dermatology outpatient clinic between January 2018 and January 2020 were retrospectively analyzed. 98 lichen planus cases, age- and sex-matched 99 controls, 197 cases in total were included in the study.
Of the 98 lichen planus cases included in the study, 60 (61%) were women. The mean age of the patients was 49.3 ± 14.4, and the average disease duration was 33.5 ± 31.4 months. 55 (55%) of the patients in the control group were female, and the mean age of the control group was 50 ± 13.2. The body mass index of LP cases was 29.5 ± 5.8, in the control group was 25.8 ± 3.7. Metabolic syndrome was found in 47 (48%) of 98 cases with lichen planus and 32.3% in the control group. MS in the lichen planus group was significantly higher than the control group (P = .025). Metabolic syndrome was detected in the oral lichen planus at the rate of 60% (12 cases). Although the incidence of MS was more common in the oral lichen planus, it was not statistically significant (P = .29). While no significant relationship was found between oral disease severity and metabolic syndrome (P = .19), a significant correlation was found between cutaneous disease severity and metabolic syndrome (P = .023).
The risk of mucosal malignancy that can occur when following LP cases has been known for a long time. According to our results, caution should be taken in terms of metabolic complications in the follow-up of LP cases, especially oral LP cases.
扁平苔藓（LP）是一种特发性、慢性炎症性疾病。慢性炎症性疾病可引起代谢并发症。文献中，有关扁平苔藓与代谢综合征（MS）之间关系的数据有限。我们旨在评估 MS 与伴有疾病活动的扁平苔藓之间的关系。
回顾性分析 2018 年 1 月至 2020 年 1 月在皮肤科门诊诊断为扁平苔藓的患者。共纳入 98 例扁平苔藓病例、年龄和性别匹配的 99 例对照，共 197 例。
纳入研究的 98 例扁平苔藓病例中，60 例（61%）为女性。患者的平均年龄为 49.3±14.4 岁，平均病程为 33.5±31.4 个月。对照组 55 例（55%）为女性，对照组平均年龄为 50±13.2 岁。LP 病例的体重指数为 29.5±5.8，对照组为 25.8±3.7。98 例扁平苔藓病例中发现代谢综合征 47 例（48%），对照组为 32.3%。扁平苔藓组的 MS 明显高于对照组（P=0.025）。口腔扁平苔藓的 MS 发生率为 60%（12 例）。尽管口腔扁平苔藓中 MS 的发生率较高，但无统计学意义（P=0.29）。虽然口腔疾病严重程度与代谢综合征之间无显著相关性（P=0.19），但皮肤疾病严重程度与代谢综合征之间存在显著相关性（P=0.023）。
长期以来，人们一直知道扁平苔藓病例可能会发生粘膜恶性肿瘤的风险。根据我们的结果，在随访扁平苔藓病例时，特别是口腔扁平苔藓病例时，应注意代谢并发症。
