Department of Chemical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.
Department of Chemical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia; Polymer Research Center, Faculty of Science and Technology, Universiti Kebangsaan Malaysia 43600 Bangi, Selangor, Malaysia.
Carbohydr Polym. 2021 Feb 15;254:117401. doi: 10.1016/j.carbpol.2020.117401. Epub 2020 Nov 16.
Low bioavailability and poor water solubility have limited the utilization of curcumin in conventional dosing methods. As an alternative, microemulsions as drug carrier can improve curcumin delivery. A cetyltrimethylammonium bromide-nanocrystalline cellulose (CTAB-NCC)-based microemulsion was developed and its potential use as a topical delivery method for curcumin was investigated. The effect of microemulsion's particle size and its microstructure as well as the presence of the CTAB-NCC nanoparticle on the topical delivery of curcumin was studied. In vitro permeation studies showed higher penetration rate of curcumin from the oil-in-water type-microemulsions. The skin permeation profile of curcumin followed Higuchi release kinetics. Furthermore, use of the (CTAB-NCC)-based microemulsion enhanced curcumin accumulation in the skin and these system showed non cytotoxicity effect on L929 cell line. These results showed the potential of (CTAB-NCC)-based microemulsions as controlled-release topical systems for the delivery of curcumin and potentially other lipophilic drugs.
低生物利用度和差的水溶性限制了姜黄素在常规剂量方法中的利用。作为替代方法，微乳液作为药物载体可以改善姜黄素的递送。开发了一种基于十六烷基三甲基溴化铵-纳米纤维素（CTAB-NCC）的微乳液，并研究了其作为姜黄素局部递送方法的潜在用途。研究了微乳液的粒径及其微观结构以及 CTAB-NCC 纳米颗粒的存在对姜黄素局部递送的影响。体外渗透研究表明，油包水型微乳液中姜黄素的渗透速率更高。姜黄素的皮肤渗透曲线遵循 Higuchi 释放动力学。此外，使用基于（CTAB-NCC）的微乳液增强了姜黄素在皮肤中的积累，并且这些系统对 L929 细胞系没有细胞毒性作用。这些结果表明，基于（CTAB-NCC）的微乳液作为用于递送姜黄素和潜在的其他亲脂性药物的控释局部系统具有潜力。
