On deriving Murray's law from constrained minimization of flow resistance.

Murray's law, which states that the cube of the radius of a parent vessel equals the sum of the cubes of the radii of the daughter vessels, was originally derived by minimizing the cost of operation of blood flow in a single cylindrical tube. An alternative widely cited derivation by Sherman is based upon the optimization problem of minimizing the total flow resistance subject to a material constraint, and that study claimed that "Conservation of the sum of the cubes of the radii is the condition for minimal resistance whether the parent vessel divides symmetrically or asymmetrically, and whether it divides into two, three, four, or, presumably, any number of daughter vessels." In this paper we show that Sherman's analysis is flawed, since with N daughter vessels there are 2-N-1 sets of vessel radii which satisfy Murray's law but which do not yield minimal total flow resistance. Moreover, we show that when there are N daughter vessels, each with the same radius, the minimal total flow resistance is an increasing function of N for N⩾1. Since N=1 corresponds to the degenerate case of no branching at all, our result implies that bifurcation (N=2) achieves the minimal total flow resistance. Our analysis thus offers an explanation for the preponderance of bifurcations (as opposed to trifurcations or higher level branchings) in many biological systems.