Poletti Sara, Mazza Mario Gennaro, Vai Benedetta, Lorenzi Cristina, Colombo Cristina, Benedetti Francesco
Psychiatry & Clinical Psychobiology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Vita-Salute San Raffaele University, Milan, Italy.
Front Psychiatry. 2020 Dec 8;11:590095. doi: 10.3389/fpsyt.2020.590095. eCollection 2020.
Bipolar disorder (BD) is a severe psychiatric illness characterized by abnormalities in the immune/inflammatory function and in brain metabolism. Evidences suggest that inflammation may affect the levels of brain metabolites as measured by single-proton magnetic resonance spectroscopy (H-MRS). The aim of the study was to investigate whether a wide panel of inflammatory markers (i.e., cytokines, chemokines, and growth factors) can predict brain metabolite concentrations of glutamate, -inositol, -acetylaspartate, and glutathione in a sample of 63 bipolar patients and 49 healthy controls. Three cytokines influenced brain metabolite concentrations: IL-9 positively predicts glutamate, IL-1β positively predicts -inositol, and CCL5 positively predicts -acetylaspartate concentrations. Furthermore, patients showed higher concentrations of glutamate, -inositol, and glutathione and lower concentrations of -acetylaspartate in respect to healthy controls. Our results confirm that inflammation in BD alters brain metabolism, through mechanisms possibly including the production of reactive oxygen species and glia activation.
双相情感障碍（BD）是一种严重的精神疾病，其特征在于免疫/炎症功能和脑代谢异常。有证据表明，炎症可能会影响通过单质子磁共振波谱（H-MRS）测量的脑代谢物水平。本研究的目的是调查一组广泛的炎症标志物（即细胞因子、趋化因子和生长因子）是否能够预测63例双相情感障碍患者和49例健康对照样本中谷氨酸、肌醇、N-乙酰天门冬氨酸和谷胱甘肽的脑代谢物浓度。三种细胞因子影响脑代谢物浓度：IL-9正向预测谷氨酸，IL-1β正向预测肌醇，CCL5正向预测N-乙酰天门冬氨酸浓度。此外，与健康对照相比，患者的谷氨酸、肌醇和谷胱甘肽浓度较高，而N-乙酰天门冬氨酸浓度较低。我们的结果证实，双相情感障碍中的炎症会改变脑代谢，其机制可能包括活性氧的产生和胶质细胞激活。
