Department of Biophysics, Faculty of Medicine, Mersin University, Mersin, Türkiye.
Department of Biophysics, Faculty of Medicine, Gaziantep University, Gaziantep, Türkiye.
Bioelectromagnetics. 2021 Feb;42(2):128-145. doi: 10.1002/bem.22314. Epub 2020 Dec 25.
Achilles tendon injuries are a common cause of complications including adhesions and tendon degeneration. As a result of these complications, the biomechanical properties are lost. Extracorporeal shockwave therapy (ESWT) and pulsed electromagnetic field (PEMF) recover the injured tendon structure; however, detailed studies of changes in tendon biomechanical properties are limited. We hypothesized that PEMF application would improve Achilles tendon biomechanical properties similar to ESWT. The curative effects of a PEMF 4-week application (15 Hz, 1 mT, 260 µs, 1 h/day) and ESWT (3 doses/28 days, 1st dose: 0.12 mJ/mm , 15 Hz, 300 impulses; 2nd dose: 0.14 mJ/mm , 15 Hz, 500 impulses; 3rd dose: 0.14 mJ/mm , 15 Hz, 500 impulses) on rabbits with Achilles tendon injury were investigated in terms of histopathological and biomechanical properties. The clinical feasibility of PEMF application was evaluated by comparing the results of both methods. Fifty New Zealand female rabbits were divided into two groups to be used in either biomechanical or immunohistochemical studies. Each of the two groups was further divided into five groups: C (Control), SH (Sham), TI (tendon injury), TI + ESWT, and TI + PEMF. Biomechanical evaluations revealed that maximum load, toughness, and maximum stress averages of the TI + PEMF group significantly increased (P < 0.05). When immunohistochemical images of the TI + PEMF group were compared with those of the TI group, the amount of fibrous tissue was less, the homogeneity of collagen fibers recovered, and collagen organization was more uniform. We conclude that both ESWT and PEMF are equally efficient for Achilles tendon recovery. PEMF application is effective and can be used in the clinic as a painless alternative treatment method. © 2020 Bioelectromagnetics Society.
跟腱损伤是导致粘连和跟腱退变等并发症的常见原因。由于这些并发症的存在,跟腱的生物力学性能丧失。体外冲击波疗法(ESWT)和脉冲电磁场(PEMF)可恢复受伤的跟腱结构;然而,关于跟腱生物力学特性变化的详细研究还很有限。我们假设 PEMF 的应用将改善跟腱的生物力学特性,类似于 ESWT。研究人员通过研究 PEMF(15Hz,1mT,260μs,每天 1 小时)应用 4 周和 ESWT(28 天内 3 次剂量,第 1 次剂量:0.12mJ/mm ,15Hz,300 个脉冲;第 2 次剂量:0.14mJ/mm ,15Hz,500 个脉冲;第 3 次剂量:0.14mJ/mm ,15Hz,500 个脉冲)对跟腱损伤兔子的组织病理学和生物力学特性的影响,来验证 PEMF 的疗效。通过比较这两种方法的结果,评估了 PEMF 应用的临床可行性。50 只新西兰雌性兔子被分为两组,分别用于生物力学或免疫组织化学研究。每组进一步分为 5 组:C(对照组)、SH(假手术组)、TI(跟腱损伤组)、TI+ESWT 组和 TI+PEMF 组。生物力学评估结果显示,TI+PEMF 组的最大载荷、韧性和最大应力平均值显著增加(P<0.05)。与 TI 组相比,TI+PEMF 组的免疫组织化学图像中,纤维组织的数量减少,胶原纤维的均匀性恢复,胶原组织更加均匀。我们得出结论,ESWT 和 PEMF 对跟腱恢复同样有效。PEMF 的应用是有效的,可以作为一种无痛的替代治疗方法在临床上使用。2020 年生物电磁学会。
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