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脉冲电磁场与体外冲击波疗法治疗兔跟腱实验性损伤的效果比较。

Comparison of the Effects of Pulsed Electromagnetic Field and Extracorporeal Shockwave Therapy in a Rabbit Model of Experimentally Induced Achilles Tendon Injury.

机构信息

Department of Biophysics, Faculty of Medicine, Mersin University, Mersin, Türkiye.

Department of Biophysics, Faculty of Medicine, Gaziantep University, Gaziantep, Türkiye.

出版信息

Bioelectromagnetics. 2021 Feb;42(2):128-145. doi: 10.1002/bem.22314. Epub 2020 Dec 25.


DOI:10.1002/bem.22314
PMID:33368423
Abstract

Achilles tendon injuries are a common cause of complications including adhesions and tendon degeneration. As a result of these complications, the biomechanical properties are lost. Extracorporeal shockwave therapy (ESWT) and pulsed electromagnetic field (PEMF) recover the injured tendon structure; however, detailed studies of changes in tendon biomechanical properties are limited. We hypothesized that PEMF application would improve Achilles tendon biomechanical properties similar to ESWT. The curative effects of a PEMF 4-week application (15 Hz, 1 mT, 260 µs, 1 h/day) and ESWT (3 doses/28 days, 1st dose: 0.12 mJ/mm , 15 Hz, 300 impulses; 2nd dose: 0.14 mJ/mm , 15 Hz, 500 impulses; 3rd dose: 0.14 mJ/mm , 15 Hz, 500 impulses) on rabbits with Achilles tendon injury were investigated in terms of histopathological and biomechanical properties. The clinical feasibility of PEMF application was evaluated by comparing the results of both methods. Fifty New Zealand female rabbits were divided into two groups to be used in either biomechanical or immunohistochemical studies. Each of the two groups was further divided into five groups: C (Control), SH (Sham), TI (tendon injury), TI + ESWT, and TI + PEMF. Biomechanical evaluations revealed that maximum load, toughness, and maximum stress averages of the TI + PEMF group significantly increased (P < 0.05). When immunohistochemical images of the TI + PEMF group were compared with those of the TI group, the amount of fibrous tissue was less, the homogeneity of collagen fibers recovered, and collagen organization was more uniform. We conclude that both ESWT and PEMF are equally efficient for Achilles tendon recovery. PEMF application is effective and can be used in the clinic as a painless alternative treatment method. © 2020 Bioelectromagnetics Society.

摘要

跟腱损伤是导致粘连和跟腱退变等并发症的常见原因。由于这些并发症的存在,跟腱的生物力学性能丧失。体外冲击波疗法(ESWT)和脉冲电磁场(PEMF)可恢复受伤的跟腱结构;然而,关于跟腱生物力学特性变化的详细研究还很有限。我们假设 PEMF 的应用将改善跟腱的生物力学特性,类似于 ESWT。研究人员通过研究 PEMF(15Hz,1mT,260μs,每天 1 小时)应用 4 周和 ESWT(28 天内 3 次剂量,第 1 次剂量:0.12mJ/mm ,15Hz,300 个脉冲;第 2 次剂量:0.14mJ/mm ,15Hz,500 个脉冲;第 3 次剂量:0.14mJ/mm ,15Hz,500 个脉冲)对跟腱损伤兔子的组织病理学和生物力学特性的影响,来验证 PEMF 的疗效。通过比较这两种方法的结果,评估了 PEMF 应用的临床可行性。50 只新西兰雌性兔子被分为两组,分别用于生物力学或免疫组织化学研究。每组进一步分为 5 组:C(对照组)、SH(假手术组)、TI(跟腱损伤组)、TI+ESWT 组和 TI+PEMF 组。生物力学评估结果显示,TI+PEMF 组的最大载荷、韧性和最大应力平均值显著增加(P<0.05)。与 TI 组相比,TI+PEMF 组的免疫组织化学图像中,纤维组织的数量减少,胶原纤维的均匀性恢复,胶原组织更加均匀。我们得出结论,ESWT 和 PEMF 对跟腱恢复同样有效。PEMF 的应用是有效的,可以作为一种无痛的替代治疗方法在临床上使用。2020 年生物电磁学会。

相似文献

[1]
Comparison of the Effects of Pulsed Electromagnetic Field and Extracorporeal Shockwave Therapy in a Rabbit Model of Experimentally Induced Achilles Tendon Injury.

Bioelectromagnetics. 2021-2

[2]
Effects of Pulsed Electromagnetic Field Therapy on Rat Achilles Tendon Healing.

J Orthop Res. 2019-10-15

[3]
Mechanical Stimulation (Pulsed Electromagnetic Fields "PEMF" and Extracorporeal Shock Wave Therapy "ESWT") and Tendon Regeneration: A Possible Alternative.

Front Aging Neurosci. 2015-11-9

[4]
An experimental study on the application of extracorporeal shock waves in the treatment of tendon injuries: preliminary report.

J Orthop Sci. 2001

[5]
Pulsed magnetic and electromagnetic fields in experimental achilles tendonitis in the rat: a prospective randomized study.

Arch Phys Med Rehabil. 1997-4

[6]
The Effects of Corticosteroid Injection in the Healthy and Damaged Achilles Tendon Model: Histopathological and Biomechanical Experimental Study in Rats.

Turk Patoloji Derg. 2020

[7]
Pulsed electromagnetic field therapy improves tendon-to-bone healing in a rat rotator cuff repair model.

J Orthop Res. 2017-4

[8]
Substantial Biomechanical Improvement by Extracorporeal Shockwave Therapy After Surgical Repair of Rodent Chronic Rotator Cuff Tears.

Am J Sports Med. 2019-6-17

[9]
Effects of extracorporeal shockwave therapy on nanostructural and biomechanical responses in the collagenase-induced Achilles tendinitis animal model.

Lasers Med Sci. 2012-1-25

[10]
Effects of pulsed electromagnetic field (PEMF) on the tensile biomechanical properties of diabetic wounds at different phases of healing.

PLoS One. 2018-1-11

引用本文的文献

[1]
Peritendinous adhesion: Therapeutic targets and progress of drug therapy.

Comput Struct Biotechnol J. 2023-11-30

[2]
Biological response of extracorporeal shock wave therapy to tendinopathy (review).

Front Vet Sci. 2022-7-22

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