Department of Ophthalmology, Peking University Shenzhen Hospital, 1120 Lianhua Road, Shenzhen, Guangdong 518036 China,
Plast Reconstr Surg. 2021 Jan 1;147(1):69-75. doi: 10.1097/PRS.0000000000007449.
Worldwide application of hyaluronic acid has brought about severe complications, including central retinal arterial occlusion, which leads to a deleterious effect on vision. The current study explored the efficacy of superselective arterial hyaluronidase thrombolysis in rabbit retinal artery occlusion induced by hyaluronic acid.
Occlusion of the internal/external ophthalmic artery in New Zealand White rabbits was induced with superselective injection of hyaluronic acid. Superselective subtraction angiography and fundus examination were conducted to confirm and evaluate the artery embolism. After 30 minutes of embolism, hyaluronidase was injected in the occluded artery through superselective arterial intubation.
Compared with preoperative and contralateral eyes, the postoperative eyes showed the symptoms of central retinal arterial occlusion and embolization, confirmed by digital subtraction angiography. After intraarterial hyaluronidase thrombolysis, the embolization failed to dissolve as shown on funduscopic and angiographic examinations.
Superselective ophthalmic artery intervention could accurately and successfully establish the animal models of retinal artery occlusion induced by hyaluronic acid. The precise occlusion site of the retinal artery and complete embolism were confirmed by ophthalmologic examinations. Intraarterial hyaluronidase thrombolysis might not be an effective method to treat retinal artery occlusion induced by hyaluronic acid.
透明质酸在全球范围内的应用带来了严重的并发症，包括视网膜中央动脉阻塞，这对视力造成了有害影响。本研究探讨了超选择性动脉内透明质酸酶溶栓治疗透明质酸诱导的兔视网膜动脉阻塞的疗效。
通过超选择性注射透明质酸诱导新西兰白兔的内外眼动脉阻塞。通过超选择性动脉插管，在栓塞后 30 分钟向闭塞动脉内注射透明质酸酶。
与术前和对侧眼相比，术后眼出现了视网膜中央动脉阻塞和栓塞的症状，数字减影血管造影证实了这一点。动脉内透明质酸酶溶栓后，眼底和血管造影检查均显示栓塞未溶解。
超选择性眼动脉介入可以准确、成功地建立透明质酸诱导的视网膜动脉阻塞动物模型。眼科检查可准确确认视网膜动脉的精确闭塞部位和完全栓塞。动脉内透明质酸酶溶栓可能不是治疗透明质酸诱导的视网膜动脉阻塞的有效方法。
