Department of Radiology, Gaziosmanpasa University School of Medicine, Gaziosmanpasa University, Tokat, Turkey.
Department of Biomedical Engineering, Faculty of Engineering, Baskent University, Ankara, Turkey.
Curr Med Imaging. 2021;17(6):741-750. doi: 10.2174/0929867328666201228124621.
Ulcerative colitis (UC) and Crohn's disease (CD) are two varieties of inflammatory bowel disease (IBD). Clinicians need a monitoring technique in the IBD. The disease activity can be assessed with endoscopy, activity indexes, and imaging techniques. Color Doppler US (CDUS) is also a non-invasive, radiation, and contrast material free examination which shows the intramural blood flow.
To evaluate the usefulness of B-mode, CDUS, and a newly developed software Color Quantification (CQ) to determine the activity of the IBD.
The disease activity was assessed by clinical activity indexes. Caecum, terminal ileum, ascending colon, transverse colon, and descending colon were evaluated by B-mode, CDUS, and the CQ. Bowel wall thickness (BWT), loss of bowel stratification, loss of haustration, and the presence of enlarged lymph nodes, mesenteric masses, abscesses, fistula, visual vascular signal patterns of the bowel as "hypo and hyper-flow" and the CQ values were investigated. BWT was compared with laboratory results and clinical activities. Vascular signal patterns and the CQ values were compared with BWT and clinical activity. The diagnostic performances of the CQ were investigated.
Fifty-two patients with IBD were evaluated. Patients with increased BWT at the transverse colon had an increased frequency of "hyper-flow" pattern. Clinically active patients had an increased incidence of "hyper-flow" pattern at the terminal ileum, ascending colon, and whole segments. They had increased CQ values at the terminal ileum, ascending colon, and descending colon, and whole segments. A cut-off value for the CQ (24.7%) was obtained at the terminal ileum. In the diagnostic performances of CQ, we observed utilities significantly at the ascending colon, descending colon, terminal ileum, and whole segments. There was a positive correlation between the CQ values and BWT at the caecum, ascending colon, transverse colon, and descending colon.
Increased visual vascular signal scores and CQ values might be useful for monitoring the disease activity in patients with IBD.
溃疡性结肠炎（UC）和克罗恩病（CD）是两种炎症性肠病（IBD）。临床医生在 IBD 中需要一种监测技术。可以通过内窥镜检查、活动指数和影像学技术来评估疾病活动。彩色多普勒超声（CDUS）也是一种非侵入性、无辐射、无造影剂的检查，可以显示壁内血流。
评估 B 模式、CDUS 和新开发的 Color Quantification（CQ）软件在确定 IBD 活动中的有用性。
通过临床活动指数评估疾病活动。通过 B 模式、CDUS 和 CQ 评估盲肠、末端回肠、升结肠、横结肠和降结肠。研究了肠壁厚度（BWT）、肠分层丢失、蠕动丢失、增大的淋巴结、肠系膜肿块、脓肿、瘘管的存在，以及肠道的“低血流和高血流”视觉血管信号模式和 CQ 值。比较 BWT 与实验室结果和临床活动。比较血管信号模式和 CQ 值与 BWT 和临床活动。研究了 CQ 的诊断性能。
评估了 52 例 IBD 患者。横结肠 BWT 增加的患者“高血流”模式的频率增加。临床上活跃的患者在末端回肠、升结肠和全段出现“高血流”模式的发生率增加。他们在末端回肠、升结肠和降结肠以及全段的 CQ 值增加。在末端回肠获得 CQ 的截断值（24.7%）。在 CQ 的诊断性能中，我们在升结肠、降结肠、末端回肠和全段观察到明显的效用。CQ 值与盲肠、升结肠、横结肠和降结肠的 BWT 呈正相关。
增加的视觉血管信号评分和 CQ 值可能有助于监测 IBD 患者的疾病活动。
