Department of Thoracic Surgery, San Raffaele Hospital, Via Olgettina, 60-20132 Milan, Italy.
School of Medicine, Vita-Salute San Raffaele University, 60-20132 Milan, Italy.
Medicina (Kaunas). 2020 Dec 24;57(1):10. doi: 10.3390/medicina57010010.
: The histological classification and staging of thymic tumors remains a matter of debate. The correlation of computed tomography (CT) parameters with tumor histology and stage also still has to be completely assessed. The aim of this study was therefore to analyze the correlation of radiological parameters with histological and staging classifications of thymomas evaluating their prognostic role. : Data of 50 patients with thymoma submitted to a complete surgical treatment between 2005 and 2015 were retrospectively analyzed. Tumors were classified according to the WHO and Suster and Moran (S&M) histological classifications and to the Masaoka-Koga and tumor, node and metastases (TNM) staging systems. The correlation of CT features with histology and stage and the prognostic role of histopathological and radiological features were assessed. : Five-year overall (OS) and disease-free survival (DFS) were 90.3% and 81.1%, respectively. A significant correlation of DFS with the Masaoka-Koga ( = 0.001) and TNM staging systems ( = 0.002) and with the S&M ( = 0.02) and WHO histological classifications ( = 0.04) was observed. CT scan features correlated with tumor stage, histology and prognosis. Moderately differentiated tumors (WHO B3) had a significantly higher incidence of irregular shape and contours ( = 0.002 and = 0.001, respectively) and pericardial contact ( = 0.036). A larger tumor volume ( = 0.03) and a greater length of pleural contact ( = 0.04) adversely influenced DFS. The presence of pleural ( < 0.001) or lung invasion ( = 0.02) and of pleural effusion ( = 0.004) was associated with a significantly worse OS. : Pre-operative CT scan parameters correlate with stage and histology, and have a prognostic role in surgically treated thymomas.
胸腺肿瘤的组织学分类和分期仍然存在争议。计算机断层扫描（CT）参数与肿瘤组织学和分期的相关性也仍有待完全评估。因此，本研究旨在分析影像学参数与胸腺瘤组织学和分期分类的相关性，评估其预后作用。
回顾性分析了 2005 年至 2015 年间接受完全手术治疗的 50 例胸腺瘤患者的数据。肿瘤根据世界卫生组织（WHO）和 Suster and Moran（S&M）组织学分类以及 Masaoka-Koga 和肿瘤、淋巴结和转移（TNM）分期系统进行分类。评估了 CT 特征与组织学和分期的相关性，以及组织病理学和影像学特征的预后作用。
5 年总生存率（OS）和无病生存率（DFS）分别为 90.3%和 81.1%。DFS 与 Masaoka-Koga（ = 0.001）和 TNM 分期系统（ = 0.002）以及 S&M（ = 0.02）和 WHO 组织学分类（ = 0.04）显著相关。CT 扫描特征与肿瘤分期、组织学和预后相关。中度分化肿瘤（WHO B3）更常出现不规则形状和轮廓（ = 0.002 和 = 0.001）和心包接触（ = 0.036）。较大的肿瘤体积（ = 0.03）和更大的胸膜接触长度（ = 0.04）对 DFS 有不利影响。存在胸膜（ < 0.001）或肺侵犯（ = 0.02）和胸腔积液（ = 0.004）与 OS 显著相关。
术前 CT 扫描参数与分期和组织学相关，对手术治疗的胸腺瘤具有预后作用。
