Department of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon 51472, Korea.
Medicina (Kaunas). 2020 Dec 23;57(1):4. doi: 10.3390/medicina57010004.
: preserved ratio impaired spirometry (PRISm) is a common spirometric pattern that causes respiratory symptoms, systemic inflammation, and mortality. However, its impact on health-related quality of life (HRQOL) and its associated factors remain unclear. We aimed to identify these HRQOL-related factors and investigate the differences in HROOL between persons with PRISm and those with normal lung function. we reviewed the Korea National Health and Nutrition Examination Survey data from 2008 to 2013 to evaluate the HRQOL of persons with PRISm, as measured while using the Euro Quality of Life-5D (EQ-5D) and identify any influencing factors. PRISm was defined as pre-bronchodilator forced expiratory volume in 1 s (FEV) <80% predicted and FEV to forced vital capacity (FVC) ratio (FEV/FVC) ≥0.7. Individuals with FEV ≥80% predicted and FEV1/FVC ≥0.7 were considered as Controls. of the 27,824 participants over the age of 40 years, 1875 had PRISm. The age- and sex-adjusted EQ-5D index was lower in the PRISm group than in the control group (PRISm, 0.930; control, 0.941; = 0.005). The participants with PRISm showed a significantly higher prevalence of hypertension ( < 0.001), diabetes ( < 0.001), obesity ( < 0.001), low physical activity ( = 0.001), ever-smoker ( < 0.001), and low income ( = 0.034) than those in the control group. In participants with PRISm, lower EQ-5D index scores were independently associated with old age ( = 0.002), low income ( < 0.001), low education level ( < 0.001), and no economic activity ( < 0.001). Three out of five EQ-5D dimensions (mobility, self-care, and usual activity) indicated a higher proportion of dissatisfied participants in the PRISm group than the control group. the participants with PRISm were identified to have poor HRQOL when compared to those without PRISm. Old age and low socioeconomic status play important roles in HRQOL deterioration in patients with PRISm. By analyzing risk factors that are associated with poor HRQOL, early detection and intervention of PRISm can be done in order to preserve patients' quality of life.
: 保留比值受损的肺量测定（PRISm）是一种常见的肺量测定模式，可引起呼吸症状、全身炎症和死亡率。然而，其对健康相关生活质量（HRQOL）的影响及其相关因素尚不清楚。我们旨在确定这些与 HRQOL 相关的因素，并调查 PRISm 患者与肺功能正常患者之间 HRQOL 的差异。我们回顾了 2008 年至 2013 年的韩国国家健康和营养检查调查数据，以评估 PRISm 患者的 HRQOL，使用 Euro Quality of Life-5D（EQ-5D）进行评估，并确定任何影响因素。PRISm 定义为支气管扩张剂前 1 秒用力呼气量（FEV）<80%预测值和 FEV 与用力肺活量（FVC）的比值（FEV/FVC）≥0.7。FEV≥80%预测值且 FEV1/FVC≥0.7 的个体被认为是对照。在年龄超过 40 岁的 27824 名参与者中，有 1875 名患有 PRISm。PRISm 组的年龄和性别调整后的 EQ-5D 指数低于对照组（PRISm，0.930；对照组，0.941；P=0.005）。与对照组相比，PRISm 组的高血压（P<0.001）、糖尿病（P<0.001）、肥胖（P<0.001）、体力活动水平低（P=0.001）、曾吸烟者（P<0.001）和低收入者（P=0.034）的比例显著更高。在 PRISm 患者中，较低的 EQ-5D 指数评分与年龄较大（P=0.002）、收入较低（P<0.001）、教育程度较低（P<0.001）和无经济活动（P<0.001）独立相关。在 PRISm 组中，有五个 EQ-5D 维度中的三个（行动能力、自理能力和日常活动）表示不满意的参与者比例高于对照组。与没有 PRISm 的患者相比，患有 PRISm 的患者的 HRQOL 较差。年龄较大和较低的社会经济地位在 PRISm 患者的 HRQOL 恶化中起着重要作用。通过分析与较差 HRQOL 相关的危险因素，可以早期发现和干预 PRISm，以维持患者的生活质量。
