胶质母细胞瘤导致显著网络静息态功能连接和低频波动振幅的破坏。
Glioma-Induced Disruption of Resting-State Functional Connectivity and Amplitude of Low-Frequency Fluctuations in the Salience Network.
机构信息
From the Departments of Radiology (J.Y., V.H., A.I.H., B.A.V.).
New York University Grossman School of Medicine (J.Y.), New York University, New York, New York.
出版信息
AJNR Am J Neuroradiol. 2021 Mar;42(3):551-558. doi: 10.3174/ajnr.A6929. Epub 2020 Dec 31.
BACKGROUND AND PURPOSE
Cognitive challenges are prevalent in survivors of glioma, but their neurobiology is incompletely understood. The purpose of this study was to investigate the effect of glioma presence and tumor characteristics on resting-state functional connectivity and amplitude of low-frequency fluctuations of the salience network, a key neural network associated with cognition.
MATERIALS AND METHODS
Sixty-nine patients with glioma (mean age, 48.74 [SD, 14.32] years) who underwent resting-state fMRI were compared with 31 healthy controls (mean age, 49.68 [SD, 15.54] years). We identified 4 salience network ROIs: left/right dorsal anterior cingulate cortex and left/right anterior insula. Average salience network resting-state functional connectivity and amplitude of low-frequency fluctuations within the 4 salience network ROIs were computed.
RESULTS
Patients with gliomas showed decreased overall salience network resting-state functional connectivity (= .001) and increased amplitude of low-frequency fluctuations in all salience network ROIs (< .01) except in the left dorsal anterior cingulate cortex. Compared with controls, patients with left-sided gliomas showed increased amplitude of low-frequency fluctuations in the right dorsal anterior cingulate cortex (= .002 and right anterior insula (< .001), and patients with right-sided gliomas showed increased amplitude of low-frequency fluctuations in the left anterior insula (= .002). Anterior tumors were associated with decreased salience network resting-state functional connectivity (< .001) and increased amplitude of low-frequency fluctuations in the right anterior insula, left anterior insula, and right dorsal anterior cingulate cortex. Patients with high-grade gliomas had decreased salience network resting-state functional connectivity compared with healthy controls (< .05). The right anterior insula showed increased amplitude of low-frequency fluctuations in patients with grade II and IV gliomas compared with controls (< .01).
CONCLUSIONS
By demonstrating decreased resting-state functional connectivity and an increased amplitude of low-frequency fluctuations related to the salience network in patients with glioma, this study adds to our understanding of the neurobiology underpinning observable cognitive deficits in these patients. In addition to more conventional functional connectivity, amplitude of low-frequency fluctuations is a promising functional-imaging biomarker of tumor-induced vascular and neural pathology.
背景与目的
认知障碍在脑胶质瘤幸存者中较为常见，但神经生物学机制尚不完全清楚。本研究旨在探讨脑胶质瘤的存在及其肿瘤特征对突显网络静息态功能连接和低频振幅的影响，突显网络是与认知相关的关键神经网络。
材料与方法
对 69 例接受静息态 fMRI 检查的脑胶质瘤患者（平均年龄 48.74[标准差 14.32]岁）与 31 例健康对照者（平均年龄 49.68[标准差 15.54]岁）进行比较。我们确定了 4 个突显网络 ROI：左侧/右侧背侧前扣带回和左侧/右侧前岛叶。计算了 4 个突显网络 ROI 中的突显网络静息态功能连接的平均频率和低频振幅。
结果
脑胶质瘤患者的整体突显网络静息态功能连接降低（=0.001），所有突显网络 ROI 的低频振幅升高（均<.01），除左侧背侧前扣带回外。与对照组相比，左侧脑胶质瘤患者右侧背侧前扣带回和右侧前岛叶的低频振幅升高（均=0.002 和右侧前岛叶<.001），右侧脑胶质瘤患者左侧前岛叶的低频振幅升高（=0.002）。前脑肿瘤与突显网络静息态功能连接降低（<.001）和右侧前岛叶、左侧前岛叶和右侧背侧前扣带回的低频振幅升高相关。高级别脑胶质瘤患者的突显网络静息态功能连接较健康对照组降低（<.05）。与对照组相比，Ⅱ级和Ⅳ级脑胶质瘤患者的右侧前岛叶低频振幅升高（均<.01）。
结论
本研究通过显示脑胶质瘤患者静息态功能连接降低和突显网络低频振幅升高，进一步了解了这些患者认知障碍的神经生物学机制。除了更传统的功能连接外，低频振幅是肿瘤诱导的血管和神经病理学的有前途的功能成像生物标志物。
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