Kljakić Duško, Milosavljević Miloš Z, Jovanović Milan, Popović Vesna Čolaković, Raičević Saša
Department of Gynecology, General Hospital Bar, Bar, Montenegro.
Department of Pathology, University Medical Center Kragujevac, Kragujevac, Serbia.
Open Med (Wars). 2020 Dec 17;16(1):81-86. doi: 10.1515/med-2021-0205. eCollection 2021.
Several species are widely distributed in nature, but is the only species frequently isolated in hospitals. This pathogen is mainly responsible for nosocomial infection, mostly in immunocompromised hosts. A 26-year-old woman with a twin pregnancy, regularly controlled, was hospitalized at 24 + 5 weeks of gestation due to scant vaginal bleeding, lower abdominal pain, and body temperature up to 37.5°C. Gynecological examination revealed bleeding accompanied by dilatation of the cervix. The laboratory analyses revealed leukocytosis with elevated C-reactive protein (CRP). Treatment was initiated with intravenous antibiotic administration. After admission, fetal membranes spontaneously ruptured, and an extremely preterm dichorionic female twin birth occurred at 25 + 0 weeks of gestation. Both infants died two days after labor. Pathological and microbiological analyses revealed chorioamnionitis caused by . According to the antibiogram, antibiotic treatment was continued for the next 7 days. The examination of cervical and vaginal discharge samples was negative three days and two weeks after therapy. may cause spontaneous miscarriages and, in this important case, caused loss of discordant twins in an extremely preterm birth by an immunocompetent patient. Infection by cannot be excluded as a cause of discordant growth and needs to be confirmed by further research.
有几个物种在自然界中广泛分布，但该物种是医院中唯一经常分离出来的。这种病原体主要导致医院感染，大多发生在免疫功能低下的宿主中。一名26岁双胎妊娠且定期接受检查的女性，在妊娠24 + 5周时因少量阴道出血、下腹痛和体温高达37.5°C而住院。妇科检查发现有出血并伴有宫颈扩张。实验室分析显示白细胞增多且C反应蛋白（CRP）升高。开始静脉注射抗生素进行治疗。入院后，胎膜自发破裂，在妊娠25 + 0周时发生了极早产的双绒毛膜女性双胞胎出生。两个婴儿在分娩后两天死亡。病理和微生物学分析显示由该病原体引起绒毛膜羊膜炎。根据抗菌谱，接下来继续进行了7天的抗生素治疗。治疗后三天和两周，宫颈和阴道分泌物样本检查均为阴性。该病原体可能导致自然流产，在这个重要病例中，导致了一名免疫功能正常的患者极早产时双胎之一丢失。不能排除该病原体感染是双胎生长不一致的原因，需要进一步研究来证实。
