Department of Child and Adolescent Psychiatry, Suleyman Demirel University Medicine Faculty, Çünür, East Campus, Isparta, 32260, Turkey.
Department of Psychiatry, Suleyman Demirel University Medicine Faculty, Isparta, Turkey.
J Autism Dev Disord. 2021 Oct;51(10):3564-3574. doi: 10.1007/s10803-020-04820-w. Epub 2021 Jan 3.
The aim of this study was to determine whether serum VEGF, IGF-1, and HIF-1α levels differed between Autism Spectrum Disorder (ASD) patients and healthy controls. A total of 40 children with ASD and 40 healthy controls aged 4-12 years were included. Serum levels of VEGF, IGF-1, and HIF-1α were measured using commercial enzyme-linked immunosorbent assay kits. Serum IGF-1 levels were found to be statistically significantly higher in the ASD group than in the control group. Serum HIF-1α levels were borderline significantly lower in the ASD group. There was no statistically significant difference in serum VEGF levels between the two groups. IGF-1 and HIF-1α may play a potential role in the etiopathogenesis of ASD.
本研究旨在确定自闭症谱系障碍（ASD）患者与健康对照组之间血清 VEGF、IGF-1 和 HIF-1α 水平是否存在差异。共纳入 40 名 4-12 岁的 ASD 患儿和 40 名健康对照者。采用商业酶联免疫吸附试验试剂盒测定血清 VEGF、IGF-1 和 HIF-1α 水平。结果发现，ASD 组血清 IGF-1 水平显著高于对照组。ASD 组血清 HIF-1α 水平显著降低，但差异无统计学意义。两组间血清 VEGF 水平无统计学差异。IGF-1 和 HIF-1α 可能在 ASD 的发病机制中发挥潜在作用。
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