Faculty of Health Sciences, School of Psychology, Curtin University, Bentley.
Faculty of Health and Medical Sciences, School of Medicine, University of Western Australia, Perth.
Curr Opin Endocrinol Diabetes Obes. 2021 Apr 1;28(2):174-180. doi: 10.1097/MED.0000000000000609.
Elevated lipoprotein(a) [Lp(a)] is a genetic trait that indicates higher risk of atherosclerotic cardiovascular disease (ASCVD). We review novel strategies to mitigate behavioural risk-factors in this genetic condition.
Pharmacological and biological interventions are available for lowering Lp(a). However, the acceptability and feasibility of these approaches are questionable due to cost and lack of clinical evidence for their efficacy. A number of low-cost, minimal patient contact interventions are available for modifying behavioural risk-factors that are associated with increased risk of ASCVD familial hypercholesterolaemia and diabetes. These include lifestyle interventions designed to improve diet and physical activity. These interventions may be particularly important among individuals with elevated Lp(a) to manage their higher risk of diabetes and ASCVD. The following article outlines recent research that has examined such low-cost, minimal patient contact interventions.
The current research indicated that such interventions, which are grounded in psychological theory, can assist individuals to improve their diet and physical activity. These findings have implications for developing and implementing similar interventions for individuals with elevated Lp(a), so as to assist in reducing behavioural risk-factors associated with ASCVD.
脂蛋白(a)升高[Lp(a)]是一种遗传特征，表明患动脉粥样硬化性心血管疾病（ASCVD）的风险更高。我们综述了减轻这种遗传情况下行为风险因素的新策略。
目前已有降低 Lp(a)的药物和生物学干预措施。然而，由于成本问题以及缺乏疗效的临床证据，这些方法的可接受性和可行性值得怀疑。有许多低成本、患者接触最少的干预措施可用于改变与 ASCVD 家族性高胆固醇血症和糖尿病风险增加相关的行为风险因素。其中包括旨在改善饮食和身体活动的生活方式干预措施。对于 Lp(a)升高的个体来说，这些干预措施可能特别重要，有助于管理其糖尿病和 ASCVD 的高风险。本文概述了最近研究，该研究检查了这些低成本、患者接触最少的干预措施。
目前的研究表明，这些基于心理理论的干预措施可以帮助个体改善饮食和身体活动。这些发现对于为 Lp(a)升高的个体制定和实施类似的干预措施具有重要意义，有助于降低与 ASCVD 相关的行为风险因素。
