Institute of Reproductive and Child Health, Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing 100191, PR China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, PR China.
Institute of Geographic Sciences and Natural Resources Research, CAS, Beijing 100101, PR China.
Ecotoxicol Environ Saf. 2021 Jan 15;208:111632. doi: 10.1016/j.ecoenv.2020.111632. Epub 2020 Nov 18.
Titanium (Ti) is commonly used in additives in the form of titanium dioxide (TiO). However, our understanding of the effect of Ti on reproductive health remains limited. This nested case-control study, performed in a Ti mining exposure field, investigated the association between maternal blood Ti concentration and the risk of low birth weight (LBW), as well as the potential biological mechanism. A total of 45 women who delivered LBW infants (cases) and 352 women with normal birth weight infants (controls) were included. We collected maternal peripheral blood samples in the first or early second trimester to measure Ti concentration in serum (Ti) and blood cells (Ti), as well as inflammatory, lipid, and oxidative stress biomarkers thereof. The demographic characteristics of the women included in the study were also obtained. The results showed that the median total blood Ti concentration (Ti) in the case group was significantly higher than that in the control group (134 vs. 129 ng/mL, P = 0.039). A higher Ti level was associated with a greater risk of LBW [odds ratio = 2.62; 95% confidence interval (CI): 1.16-5.90], but no such association was observed for Ti or Ti after adjusting for potential confounders. The serum lipid biomarkers TC, TG, and total lipids (TL) were all negatively associated with Ti and Ti. Serum 8-OHdG was positively associated with Ti. We concluded that a high Ti during early pregnancy may increase the risk of LBW. Lipid metabolism and oxidative stress may play an important role in the adverse health effects associated with Ti exposure. Thus, our results merit more attention to the probable adverse effects of titanium exposure during pregnancy.
钛（Ti）通常以二氧化钛（TiO）的形式作为添加剂使用。然而，我们对 Ti 对生殖健康的影响的了解仍然有限。本巢式病例对照研究在 Ti 矿区进行，旨在探讨母体血液 Ti 浓度与低出生体重（LBW）风险之间的关系，并探讨潜在的生物学机制。共纳入 45 名分娩 LBW 婴儿的母亲（病例）和 352 名分娩正常体重婴儿的母亲（对照）。我们在妊娠早期或中期采集了母亲的外周血样，以测量血清（Ti）和血细胞（Ti）中的 Ti 浓度，以及炎症、脂质和氧化应激生物标志物。还收集了纳入研究的女性的人口统计学特征。结果显示，病例组的总血 Ti 浓度（Ti）中位数明显高于对照组（134 比 129ng/ml，P=0.039）。较高的 Ti 水平与 LBW 的风险增加相关[比值比=2.62；95%置信区间（CI）：1.16-5.90]，但在调整了潜在混杂因素后，Ti 或 Ti 与 LBW 之间没有这种关联。血清脂质生物标志物 TC、TG 和总脂质（TL）均与 Ti 和 Ti 呈负相关。血清 8-OHdG 与 Ti 呈正相关。我们得出结论，妊娠早期 Ti 含量较高可能会增加 LBW 的风险。脂质代谢和氧化应激可能在与 Ti 暴露相关的不良健康影响中发挥重要作用。因此，我们的研究结果值得更多关注钛暴露在妊娠期间可能产生的不良影响。
