治疗 LUTS/BPH 的 Rezūm 水蒸气热疗有何新进展？
What Is New with Rezūm Water Vapor Thermal Therapy for LUTS/BPH?
机构信息
Division of Urology, Robert Wood Johnson Medical School, 1 Robert Wood Johnson Place, New Brunswick, NJ, 08901, USA.
出版信息
Curr Urol Rep. 2021 Jan 6;22(1):4. doi: 10.1007/s11934-020-01018-6.
PURPOSE OF REVIEW
Rezum® is a novel convection-based thermal therapy for benign prostatic hyperplasia (BPH) induced lower urinary tract symptoms (LUTS). This review provides an overview of its safety, efficacy, cost, and potential role in the paradigm of BPH/LUTS therapies.
RECENT FINDINGS
Data regarding Rezum® stems primarily from one large randomized controlled trial of 197 patients with 4 years of follow-up. The efficacy and safety of Rezum® is further supported by 4 additional studies including 1 prospective pilot study, 1 crossover study, and 2 retrospective studies. Durable improvements in IPSS (47-60%), QoL (38-52%), Qmax (45-72%), and PVR (11-38%) were seen without causing deterioration of sexual function. Rezum® offers a cost-effective and safe approach to treating BPH/LUTS and should be considered as a possible first-line therapy for patients with moderate to severe symptoms.
目的综述
Rezum® 是一种新型的基于对流的热疗方法，用于治疗良性前列腺增生（BPH）引起的下尿路症状（LUTS）。本文综述了 Rezum® 的安全性、疗效、成本，以及其在 BPH/LUTS 治疗模式中的潜在作用。
最新发现
关于 Rezum® 的数据主要来源于一项针对 197 例患者的大型随机对照试验，随访时间为 4 年。Rezum® 的疗效和安全性还得到了另外 4 项研究的支持，包括 1 项前瞻性试点研究、1 项交叉研究和 2 项回顾性研究。Rezum® 可持久改善国际前列腺症状评分（47%-60%）、生活质量评分（38%-52%）、最大尿流率（45%-72%）和膀胱残余尿量（11%-38%），而不会导致性功能恶化。Rezum® 是一种治疗 BPH/LUTS 的有效且安全的方法，应考虑作为中重度症状患者的一线治疗选择。
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