韩国患者短 QT 间期的长期预后：一项多中心回顾性队列研究。
Long-term prognosis of short QT interval in Korean patients: a multicenter retrospective cohort study.
机构信息
Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro Seodaemun-gu, Seoul, 03722, Republic of Korea.
Division of Cardiology, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, Gyunggi-do, Republic of Korea.
出版信息
BMC Cardiovasc Disord. 2021 Jan 6;21(1):17. doi: 10.1186/s12872-020-01824-3.
BACKGROUND
Short QT syndrome is a rare, inherited channelopathy associated with sudden cardiac arrest (SCA) but the characteristics and prognosis of short QT interval (SQTI) in Korean patients remain unclear. This study aimed to determine the clinical characteristics and outcomes of SQTI in a Korean population.
METHODS
Consecutive patients with SQTI from January 1999 to March 2019 in three university hospitals in South Korea were recruited. SQTI was defined as a Bazett's formula-corrected QT interval (QTc) ≤ 340 ms in serial electrocardiograms. Age- and sex-matched patients with a normal QTc and without overt cardiovascular disease were included in a 1:4 ratio. Clinical and ECG features and outcomes were compared between patients with and without SQTI.
RESULTS
34 patients with SQTI [age, 23.5 (21-30.5) years; 31 male] were followed up for 4.8 (2.0-7.8) years. Early repolarization, tall T wave, and U wave were significantly more frequent in patients with SQTI than in those without SQTI. QT dispersion [44.0 (28.0-73.0) vs. 20.0 (12.0-35.0) ms, P < 0.001] was significantly wider and heart rate [52.0 (47.0-58.0) vs. 70.0 (62.3-84.0)/min, P < 0.001] was significantly slower in patients with SQTI than in those without. Atrial fibrillation (AF, 11.8% vs. 2.2%, P = 0.030) and ventricular arrhythmia (VA)/SCA (8.7% vs. 0%, P = 0.007) were significantly more frequent in patients with SQTI than in those without. SQTI was significantly associated with AF [odds ratio, 5.911; 95% confidence interval, 1.257-27.808; P = 0.025] and VA/SCA.
CONCLUSIONS
In this subset of Korean population, SQTI was associated with AF and VA/SCA.
背景
短 QT 综合征是一种罕见的遗传性通道病，与心搏骤停（SCA）有关，但韩国患者短 QT 间期（SQTI）的特征和预后仍不清楚。本研究旨在确定韩国人群中 SQTI 的临床特征和结局。
方法
连续纳入 2019 年 3 月前在韩国三家大学医院就诊的 SQTI 患者。通过巴塞尔氏公式校正 QT 间期（QTc）≤340ms 定义 SQTI。按年龄和性别以 1:4 的比例纳入 QTc 正常且无明显心血管疾病的患者。比较 SQTI 患者与非 SQTI 患者的临床和心电图特征及结局。
结果
共纳入 34 例 SQTI 患者[年龄 23.5（21-30.5）岁；31 名男性]，中位随访 4.8（2.0-7.8）年。与非 SQTI 患者相比，SQTI 患者的早期复极、高大 T 波和 U 波更为常见。QT 离散度[44.0（28.0-73.0）vs. 20.0（12.0-35.0）ms，P<0.001]更大，心率[52.0（47.0-58.0）vs. 70.0（62.3-84.0）/min，P<0.001]更慢。与非 SQTI 患者相比，SQTI 患者心房颤动（AF，11.8%vs. 2.2%，P=0.030）和室性心律失常（VA）/心搏骤停（SCA，8.7%vs. 0%，P=0.007）更为常见。SQTI 与 AF[比值比，5.911；95%置信区间，1.257-27.808；P=0.025]和 VA/SCA 显著相关。
结论
在韩国人群中，SQTI 与 AF 和 VA/SCA 相关。
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