以四肢瘫为表现的颈椎原发性间变性淋巴瘤激酶阴性间变性大细胞淋巴瘤：一例报告及文献复习
Primary anaplastic lymphoma kinase-negative anaplastic large cell lymphoma of cervical spine presenting with quadriplegia: A case report and literature review.
作者信息
Basu Garga, Anthony Michael L, Bakliwal Anamika, Chattopadhyay Debranjani, Joshi Prashant P, Arora Rajnish Kumar, Mittal Radhey Shyam, Nath Uttam Kumar
机构信息
Department of Neurosurgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Department of Pathology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
出版信息
Surg Neurol Int. 2020 Nov 6;11:373. doi: 10.25259/SNI_634_2020. eCollection 2020.
BACKGROUND
An anaplastic large cell lymphoma (ALCL) involving the cervical spine and leading to quadriplegia is very rare.
CASE DESCRIPTION
A 48-year-old immunocompetent male presented with quadriplegia that warranted an anterior cervical corpectomy/fusion. He was previously being presumptively treated for cervical disease attributed to tuberculosis. The histopathology and immunohistochemistry revealed an ALCL that was anaplastic lymphoma kinase (ALK) negative. The patient had a favorable response to surgery followed by CHOEP (cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisolone) chemotherapy.
CONCLUSION
ALK-negative ALCL presenting with quadriplegia due to primary involvement of cervical spine is extremely rare, but must be diagnosed and appropriately managed.
背景
累及颈椎并导致四肢瘫痪的间变性大细胞淋巴瘤（ALCL）非常罕见。
病例描述
一名48岁免疫功能正常的男性因四肢瘫痪接受了颈椎前路椎体次全切除/融合术。他之前一直被推测性地治疗因结核病引起的颈椎疾病。组织病理学和免疫组织化学显示为ALK阴性的ALCL。该患者对手术及随后的CHOEP（环磷酰胺、阿霉素、长春新碱、依托泊苷和泼尼松龙）化疗反应良好。
结论
因颈椎原发性受累而导致四肢瘫痪的ALK阴性ALCL极为罕见，但必须予以诊断并进行适当治疗。
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