Delbarre B, Delbarre G
Laboratoire de Recherches Physiopathologiques, Faculté de Médecine, Tours, France.
Am J Med. 1988 Jan 29;84(1B):20-5.
This study quantified the immediate general hemodynamic events following the bilateral carotid ligation-induced cerebral ischemia in normotensive and spontaneously hypertensive rats. The influence of treatment with indapamide was evaluated. In normotensive rats, hemodynamic values remained unchanged during the 10 minutes following the carotid ligation. In spontaneously hypertensive rats, arterial pressure values immediately and significantly (p less than 0.01) increased, up to 50 percent during the 10 minutes following the carotid ligation. Heart rate was unchanged. Indapamide at a short-term 3 mg/kg intraperitoneally, chosen in order to give a minimal (nonsignificant) antihypertensive effect in spontaneously hypertensive rats, significantly (p less than 0.01) reduced the bilateral carotid ligation-induced vasopressor response, whereas heart rate remained unchanged. The results presented here show that in spontaneously hypertensive rats, but not in normotensive rats, bilateral common carotid ligation induces an immediate and strong increase in arterial pressure values. These results compare with the previously described differences in cerebral ischemia-induced disorders in normotensive and hypertensive rats. Finally, indapamide, an antihypertensive agent that decreases vascular reactivity, significantly inhibits the carotid ligation-induced vasopressive response in hypertensive rats.
本研究对正常血压大鼠和自发性高血压大鼠双侧颈动脉结扎诱发脑缺血后的即时全身血流动力学事件进行了量化。评估了吲达帕胺治疗的影响。在正常血压大鼠中，颈动脉结扎后的10分钟内血流动力学值保持不变。在自发性高血压大鼠中，颈动脉结扎后的10分钟内动脉压值立即显著升高（p<0.01），升高幅度高达50%。心率未发生变化。为了在自发性高血压大鼠中产生最小（无显著意义）的降压作用而选择的短期3mg/kg腹腔注射吲达帕胺，显著降低了双侧颈动脉结扎诱发的升压反应（p<0.01），而心率保持不变。此处呈现的结果表明，在自发性高血压大鼠而非正常血压大鼠中，双侧颈总动脉结扎会导致动脉压值立即大幅升高。这些结果与之前描述的正常血压和高血压大鼠脑缺血诱发疾病的差异相符。最后，作为一种降低血管反应性的抗高血压药物，吲达帕胺显著抑制了高血压大鼠颈动脉结扎诱发的升压反应。
