非编码RNA：肝细胞癌葡萄糖代谢的新兴调节因子
Non-coding RNAs: emerging regulators of glucose metabolism in hepatocellular carcinoma.
作者信息
Lai Yongting, Huang Hairong, Abudoureyimu Mubalake, Lin Xinrong, Tian Chuan, Wang Ting, Chu Xiaoyuan, Wang Rui
机构信息
Department of Medical Oncology, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University Nanjing, China.
Department of Cardiothoracic Surgery, Jinling Hospital Nanjing, China.
出版信息
Am J Cancer Res. 2020 Dec 1;10(12):4066-4084. eCollection 2020.
Reprogramming of metabolism is one of the hallmarks of cancer, among which glucose metabolism dysfunction is the most prominent feature. The glucose metabolism of tumor cells is significantly different from that of normal cells. Glucose metabolism reprogramming of hepatocellular carcinoma (HCC) has become an important research hotspot in the field of HCC, a variety of tumor metabolic interventions have been applied clinically. Moreover, various Non-coding RNAs (ncRNAs) including microRNAs (miRNAs), long non-coding (lncRNAs) as well as circular RNAs (circRNAs), have recently been proved to play potential roles in glucose metabolism. This review summarizes the effects of ncRNAs on HCC that participate in glucose metabolism and discuss the related mechanisms to find potential and effective targeted treatments for HCC.
代谢重编程是癌症的标志之一，其中葡萄糖代谢功能障碍是最突出的特征。肿瘤细胞的葡萄糖代谢与正常细胞显著不同。肝细胞癌（HCC）的葡萄糖代谢重编程已成为HCC领域的一个重要研究热点，多种肿瘤代谢干预措施已应用于临床。此外，最近已证明包括微小RNA（miRNA）、长链非编码RNA（lncRNA）以及环状RNA（circRNA）在内的各种非编码RNA（ncRNA）在葡萄糖代谢中发挥潜在作用。本综述总结了ncRNA对参与葡萄糖代谢的HCC的影响，并探讨相关机制，以寻找针对HCC的潜在有效靶向治疗方法。
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