Persian Gulf Physiology Research Center. Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Persian Gulf Physiology Research Center. Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Department of Physiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Neurosci Lett. 2021 Feb 6;745:135617. doi: 10.1016/j.neulet.2020.135617. Epub 2021 Jan 6.
Hepatic encephalopathy (HE) is a cerebral function alteration in patients with liver dysfunction. The present study aimed to evaluate the therapeutic effects of thymoquinone (TQ) on behavioral deficits and its possible mechanism(s) in a thioacetamide (TAA)-induced HE model. HE was induced in male Wistar rats by intraperitoneal (i.p.) injection of TAA (200 mg/kg) for once every 48 h for 14 consecutive days. Thymoquinone (5, 10, and 20 mg/kg) was administered for seven consecutive days (i.p.) after HE induction. Anxiety and depression-like behaviors assessed by standard paradigms respectively. Finally, their brain hippocampus sections prepared to evaluate the oxidative stress changes in rats. Data showed treatment HE rats with TQ ameliorated anxiety and depression-like behaviors. TQ administration also reduced oxidative stress due to its potential to enhance the levels of glutathione-peroxidase (GPx), catalase (CAT), and total thiol content in the hippocampus. These findings suggest that TQ has notable effects against acute hepatic failure and HE complications through modulation of oxidative stress.
肝性脑病（HE）是肝功能障碍患者的大脑功能改变。本研究旨在评估姜黄素（TQ）在硫代乙酰胺（TAA）诱导的 HE 模型中对行为缺陷的治疗作用及其可能的机制。通过腹腔（i.p.）注射 TAA（200mg/kg），每隔 48 小时一次，连续 14 天诱导雄性 Wistar 大鼠产生 HE。在诱导 HE 后，连续 7 天（i.p.）给予姜黄素（5、10 和 20mg/kg）。通过标准范式评估焦虑和抑郁样行为。最后，制备大鼠海马切片以评估其大脑中海马区氧化应激的变化。数据表明，TQ 治疗 HE 大鼠可改善焦虑和抑郁样行为。TQ 的给药还降低了氧化应激，因为它能够提高谷胱甘肽过氧化物酶（GPx）、过氧化氢酶（CAT）和总巯基含量在海马中的水平。这些发现表明，TQ 通过调节氧化应激对急性肝衰竭和 HE 并发症具有显著的作用。
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