Trajectory log analysis and cone-beam CT-based daily dose calculation to investigate the dosimetric accuracy of intensity-modulated radiotherapy for gynecologic cancer.

This study evaluated unexpected dosimetric errors caused by machine control accuracy, patient setup errors, and patient weight changes/internal organ deformations. Trajectory log files for 13 gynecologic plans with seven- or nine-beam dynamic multileaf collimator (MLC) intensity-modulated radiation therapy (IMRT), and differences between expected and actual MLC positions and MUs were evaluated. Effects of patient setup errors on dosimetry were estimated by in-house software. To simulate residual patient setup errors after image-guided patient repositioning, planned dose distributions were recalculated (blurred dose) after the positions were randomly moved in three dimensions 0-2 mm (translation) and 0°-2° (rotation) 28 times per patient. Differences between planned and blurred doses in the clinical target volume (CTV) D and D were evaluated. Daily delivered doses were calculated from cone-beam computed tomography by the Hounsfield unit-to-density conversion method. Fractional and accumulated dose differences between original plans and actual delivery were evaluated by CTV D and D . The significance of accumulated doses was tested by the paired t test. Trajectory log file analysis showed that MLC positional errors were -0.01 ± 0.02 mm and MU delivery errors were 0.10 ± 0.10 MU. Differences in CTV D and D were <0.5% for simulated patient setup errors. Differences in CTV D and D were 2.4% or less between the fractional planned and delivered doses, but were 1.7% or less for the accumulated dose. Dosimetric errors were primarily caused by patient weight changes and internal organ deformation in gynecologic radiation therapy.