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《海湾合作委员会国家甲状腺癌发病率趋势:15 年分析》。

Trends in Thyroid Cancer Incidence in the Gulf Cooperation Council States: a 15-Year Analysis.

机构信息

Department of Epidemiology and Biostatistics, Faculty of Public Health, Kuwait University, State of Kuwait.

Gulf Centre for Cancer Control and Prevention, King Faisal Special Hospital and Research Centre, Riyadh, Saudi Arabia.

出版信息

Gulf J Oncolog. 2020 Sep;1(34):31-38.

Abstract

INTRODUCTION

Thyroid cancer is a predominant malignancy in the Gulf Cooperation Council (GCC) states. Explicit regional assessments of incidence are crucial among countries that share similar demographic, cultural, and economic characteristics. This study provides an assessment of trends in thyroid cancer in the GCC over fifteen years.

METHODS

Data included cases in the GCC, reported to the Gulf Center for Cancer Registration during 1998-2012 (N=10,417). Age-specific rates, age-standardized rates (ASR), and stage at diagnosis are compared between the GCC states during 1998-2002, 2003-2007, and 2008-2012. Standardization of rates was performed using the World Standard Population.

RESULTS

Between 1998-2002 and 2008-2012, the frequency of thyroid cancer in the GCC was approximately fourfold higher in females than males. The average ASR increased from 1.8 to 2.4/100,000 for males and 5.7 to 8.4/100,000 for females. Age-specific incidence showed a shift towards a younger age for women and an older age for males. During 1998-2012, the proportion of localized stage at diagnosis ranged from 18% in Oman to 57% in the UAE. The proportion of unknown stage varied considerably among states, ranging from 13% to 64%. Over the study period, the proportion of unknown stage increased in all but two states (Bahrain and Saudi Arabia).

CONCLUSION

The incidence of thyroid cancer in the GCC has generally increased. This could reflect improved testing, leading to enhanced detection and diagnosis of thyroid cancers, as well as a possible increase in exposure to risk factors. Improved ascertainment of stage data is essential to reflect changes in early diagnosis activities.

摘要

简介

甲状腺癌是海湾合作委员会(GCC)国家的主要恶性肿瘤。在具有相似人口统计学、文化和经济特征的国家中,对发病率进行明确的区域评估至关重要。本研究评估了 GCC 地区 15 年来甲状腺癌的趋势。

方法

数据包括 1998 年至 2012 年期间向海湾癌症登记中心报告的 GCC 病例(N=10,417)。在 1998-2002 年、2003-2007 年和 2008-2012 年期间,比较了 GCC 国家之间的年龄特异性发病率、年龄标准化发病率(ASR)和诊断时的分期。使用世界标准人口对发病率进行标准化。

结果

在 1998-2002 年至 2008-2012 年期间,GCC 地区女性甲状腺癌的发病率是男性的四倍左右。男性的平均 ASR 从 1.8 增至 2.4/100,000,女性从 5.7 增至 8.4/100,000。年龄特异性发病率显示女性发病年龄向年轻化转移,男性向老龄化转移。在 1998-2012 年期间,诊断时局部分期的比例从阿曼的 18%到阿联酋的 57%不等。各国家之间未知分期的比例差异很大,范围从 13%到 64%不等。在研究期间,除了两个国家(巴林和沙特阿拉伯)之外,所有国家的未知分期比例都有所增加。

结论

GCC 地区的甲状腺癌发病率普遍增加。这可能反映了检测的改善,从而提高了甲状腺癌的检出和诊断率,以及暴露于危险因素的可能性增加。必须更好地确定分期数据,以反映早期诊断活动的变化。

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