伐地那非治疗男性勃起功能障碍的系统评价和荟萃分析。

Vardenafil in the Treatment of Male Erectile Dysfunction: A Systematic Review and Meta-Analysis.

机构信息

Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Department of Urology, Beijing Hospital, National Center of Gerontology, Beijing, China.

出版信息

Adv Ther. 2021 Feb;38(2):1301-1313. doi: 10.1007/s12325-020-01559-9. Epub 2021 Jan 11.

DOI:10.1007/s12325-020-01559-9

PMID:33432539

Abstract

INTRODUCTION

We carried out this systemic review and meta-analysis of relevant randomized controlled trials to determine different dosage regimens of vardenafil in the treatment of male erectile dysfunction (ED).

METHODS

Using appropriate keywords, we searched PubMed, the Cochrane Library, and Embase for relevant literature before March 2020. We evaluated odds ratio (OR), weighted mean difference (WMD), and 95% confidence interval (95% CI) to assess the results of each study.

RESULTS

We included 14 studies with a total of 3221 patients. Compared with the placebo, vardenafil significantly increased International Erectile Function Index (IIEF) overall satisfaction (WMD 3.37, 95% CI 2.02-4.71), IIEF-erectile function (WMD 7.93, 95% CI 6.00-9.85), IIEF sexual desire (WMD 0.79, 95% CI 0.24-1.35), IIEF intercourse satisfaction (WMD 5.24, 95% CI 3.35-7.13), IIEF orgasmic function (WMD 3.81, 95% CI 2.26-5.35), Sexual Encounter Profile (SEP) Q2 (WMD 26.36, 95% CI 22.95-29.77), and SEP Q3 (WMD 35.18, 95% CI 31.89-38.48).

CONCLUSIONS

Vardenafil demonstrated significant efficacy in the treatment of ED, but the optimal dose and course of vardenafil remain to be established.

摘要

简介

本系统评价和荟萃分析对相关随机对照试验进行了研究，旨在确定不同剂量的伐地那非治疗男性勃起功能障碍（ED）的疗效。

方法

我们使用合适的关键词在 2020 年 3 月前检索了 PubMed、Cochrane 图书馆和 Embase 中的相关文献。我们评估了比值比（OR）、加权均数差（WMD）和 95%置信区间（95%CI），以评估每项研究的结果。

结果

我们纳入了 14 项研究，共 3221 例患者。与安慰剂相比，伐地那非显著提高了国际勃起功能指数（IIEF）总体满意度（WMD 3.37，95%CI 2.02-4.71）、IIEF 勃起功能（WMD 7.93，95%CI 6.00-9.85）、IIEF 性欲（WMD 0.79，95%CI 0.24-1.35）、IIEF 性交满意度（WMD 5.24，95%CI 3.35-7.13）、IIEF 性高潮功能（WMD 3.81，95%CI 2.26-5.35）、性体验问卷（SEP）Q2（WMD 26.36，95%CI 22.95-29.77）和 SEP Q3（WMD 35.18，95%CI 31.89-38.48）。