Jensen P Ø, Møller S A, Lerche C J, Moser C, Bjarnsholt T, Ciofu O, Faurholt-Jepsen D, Høiby N, Kolpen M
Department of Clinical Microbiology, Rigshospitalet, 2100, Copenhagen, Denmark.
Costerton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health Sciences University of Copenhagen, 2200, Copenhagen, Denmark.
Biofilm. 2019 Nov 4;1:100008. doi: 10.1016/j.bioflm.2019.100008. eCollection 2019 Dec.
Bacteria and fungi show substantial increased recalcitrance when growing as infectious biofilms. Chronic infections caused by biofilm growing microorganisms is considered a major problem of modern medicine. New strategies are needed to improve antibiotic treatment of biofilms. We have improved antibiotic treatment of bacterial biofilms by reviving the dormant bacteria and thereby make them susceptible to antibiotics by means of reoxygenation. Here we review the rationale for associating lack of oxygen with low susceptibility in infectious biofilm, and how hyperbaric oxygen therapy may result in reoxygenation leading to enhanced bactericidal activity of antibiotics. We address issues of feasibility and potential adverse effects regarding patient safety and development of resistance. Finally, we propose means for supplying reoxygenation to antibiotic treatment of infectious biofilm with the potential to benefit large groups of patients.
细菌和真菌在形成感染性生物膜生长时表现出显著增强的抗降解性。由生物膜生长微生物引起的慢性感染被认为是现代医学的一个主要问题。需要新的策略来改善对生物膜的抗生素治疗。我们通过复苏休眠细菌，从而通过再给氧使其对抗生素敏感，改进了对细菌生物膜的抗生素治疗。在此，我们综述了将缺氧与感染性生物膜中低敏感性相关联的基本原理，以及高压氧疗法如何导致再给氧从而增强抗生素的杀菌活性。我们讨论了关于患者安全和耐药性发展的可行性及潜在不良反应问题。最后，我们提出了为感染性生物膜的抗生素治疗提供再给氧的方法，有可能使大量患者受益。
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