Département de Médecine Nucléaire, Hôpital Lapeyronie, Centre Hospitalier Régional Universitaire (CHRU) Montpellier, 34295, Montpellier, France.
PhyMedExp,Université de Montpellier, INSERM, CNRS, Montpellier, France.
Arch Osteoporos. 2021 Jan 14;16(1):13. doi: 10.1007/s11657-020-00870-w.
This study investigated the potential role of quantitative ultrasound (QUS) to assess low bone mass in anorexia nervosa patients (AN). Bone parameters from QUS and DXA were positively correlated and significantly reduced in AN compared with controls, suggesting that QUS is a pertinent technique to assess low bone mass in these patients.
The aim of this study was to investigate the potential role of an alternative technique, quantitative ultrasound (QUS), to assess low bone mass in patients with anorexia nervosa (AN).
Two hundred seven young women (134 patients with AN and 73 healthy controls) with ages ranging from 14.4 to 38.4 years participated in this observational cross-sectional study. Bone mass was concomitantly evaluated by DXA to determine areal bone mineral density (aBMD; g/cm) at hip, lumbar spine, and radius and by QUS to determine broadband ultrasound attenuation (BUA; dB/MHz) at the heel.
BUA (66.5 ± 4.6 dB/MHz vs 61.0 ± 5.0 dB/MHz) and aBMD at the hip (0.916 ± 0.013 g/cm vs 0.806 ± 0.010 g/cm), lumbar spine (0.966 ± 0.012 g/cm vs 0.886 ± 0.010 g/cm), and radius (0.545 ± 0.005 g/cm vs 0.526 ± 0.04 g/cm) were significantly decreased (p < 0.01) in patients with AN compared with controls. When patient and control data were pooled, BUA was significantly correlated with aBMD at the hip (r = 0.60, p < 0.001), lumbar spine (r = 0.48, p < 0.001), and radius (r = 0.40, p<0.001). In patients with AN, BUA and aBMD were mainly and positively correlated with weight, lean tissue mass, body mass index (BMI), and minimal BMI life and negatively with the duration of both disease and amenorrhea. Better concordance between the two techniques was obtained when absolute BUA and aBMD values were used according to the WHO T score classification.
BUA measurement at the heel by QUS appears to be a pertinent nonionizing technique to assess low bone mass in patients with AN.
本研究旨在探讨一种替代技术，即定量超声（QUS），在评估神经性厌食症（AN）患者低骨量中的作用。
共纳入年龄 14.4 岁至 38.4 岁的 207 名年轻女性（134 例 AN 患者和 73 名健康对照者），采用双能 X 线吸收法（DXA）同时评估骨密度，检测髋部、腰椎和桡骨的骨矿物质密度（aBMD；g/cm），采用超声骨密度仪检测跟骨的宽带超声衰减（BUA；dB/MHz）。
AN 患者的 BUA（66.5±4.6 dB/MHz 比 61.0±5.0 dB/MHz）和髋部（0.916±0.013 g/cm 比 0.806±0.010 g/cm）、腰椎（0.966±0.012 g/cm 比 0.886±0.010 g/cm）和桡骨（0.545±0.005 g/cm 比 0.526±0.04 g/cm）aBMD 均显著降低（p<0.01）。当将患者和对照组的数据合并时，BUA 与髋部（r=0.60，p<0.001）、腰椎（r=0.48，p<0.001）和桡骨（r=0.40，p<0.001）aBMD 显著相关。在 AN 患者中，BUA 与体重、瘦体重、体重指数（BMI）和最低 BMI 生活、疾病和闭经时间呈正相关，与 BUA 和 aBMD 呈正相关。根据 WHO T 评分分类，采用绝对 BUA 和 aBMD 值时，两种技术的一致性更好。
QUS 测量跟骨 BUA 似乎是评估 AN 患者低骨量的一种合适的非电离技术。
