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间充质干细胞在新冠病毒肺炎治疗中的作用。

The role of mesenchymal stem cells in COVID-19 treatment.

作者信息

Yıldız Gülhan Pınar

机构信息

Department of Chest Diseases, Düzce University Faculty of Medicine, Düzce, Turkey.

出版信息

Tuberk Toraks. 2020 Dec;68(4):430-436. doi: 10.5578/tt.69770.

Abstract

The novel coronavirus (SARS-CoV-2) pandemic has created a sense of global panic and the medical community started to search for rapid answers. Pharmaceuticals and research labs across the world are racing to find vaccines and treatments for the new coronavirus, using a variety of different technological ways. With Coronavirus disease (COVID-19), it is observed that asymptomatic symptoms turn out to be severe and fatal. By raising pyrexia, sepsis, acute respiratory distress syndrome (ARDS), and multiple organ failure are observed to develop which are not only associated with coronavirus. The treatment of the virus and the systemic inflammatory response it causes are also very important. The rapid response to infection has been well defined and comprises a complex interaction of cytokine storm, endothelial dysfunction, inflammation, and pathologic coagulation. Since the effective therapies are missing and immunological treatments may be deficient, mesenchymal stem cells (MSCs), by reason of their potent immunomodulatory ability, can have useful results in order to prevent the cytokine storm and reduce morbidity and mortality for COVID-19. The aim of this article is to discuss the potential effect of MSCs types in COVID-19 infection without definite treatment.

摘要

新型冠状病毒(SARS-CoV-2)大流行引发了全球恐慌感,医学界开始寻求快速解决方案。世界各地的制药公司和研究实验室正竞相利用各种不同技术方法来寻找针对新型冠状病毒的疫苗和治疗方法。在冠状病毒病(COVID-19)中,观察到无症状症状会发展为严重症状甚至致命。通过发热会引发脓毒症、急性呼吸窘迫综合征(ARDS),并观察到会出现多器官功能衰竭,而这些病症不仅与冠状病毒有关。对该病毒及其引发的全身炎症反应的治疗也非常重要。对感染的快速反应已得到明确界定,包括细胞因子风暴、内皮功能障碍、炎症和病理性凝血的复杂相互作用。由于缺乏有效的治疗方法且免疫治疗可能存在不足,间充质干细胞(MSCs)凭借其强大的免疫调节能力,在预防细胞因子风暴以及降低COVID-19的发病率和死亡率方面可能会产生有益效果。本文旨在探讨在没有明确治疗方法的情况下,间充质干细胞类型对COVID-19感染的潜在影响。

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