Goomer N, Saxena R N, Sheth A R
Endokrinologie. 1977 Jul;69(2):195-201.
The content of hypothalamic LHRH and concentration of LH in pituitary and plasma were measured on day 5, 7, 10, 14, 17, 22, 25, 30, 45, 52 and 60 in male rats which were bilaterally castrated on day 2. The levels of plasma LH were significantly higher in all the groups of castrated rats than in normal male rats of corresponding ages. The concentration of plasma LH did not rise progressively but showed day to day fluctuation apparently due to alteration of sexual differentiation of the hypothalamus. The concentration of pituitary LH was significantly lower in neonatally castrated rats compared to normal male rats except on days 17, 25 and 30. The content of hypothalamic LHRH declined initially following castration, but from day 17 onwards significantly higher levels of hypothalamic LHRH were maintained in neonatally castrated rats than in intact control. Initial decline in the content of hypothalamic LHRH may be because of stimulation of release of LHRH which exceeds maximal rate of synthesis and subsequent increase in the content of hypothalamic LHRH may be due to enhanced LHRH synthesis as a result of castration.
在第2天对雄性大鼠进行双侧去势，于第5、7、10、14、17、22、25、30、45、52和60天测量下丘脑促黄体激素释放激素（LHRH）的含量以及垂体和血浆中促黄体生成素（LH）的浓度。所有去势大鼠组的血浆LH水平均显著高于相应年龄的正常雄性大鼠。血浆LH浓度并非逐渐升高，而是明显呈现出每日波动，这显然是由于下丘脑性分化的改变所致。除了在第17、25和30天，新生期去势大鼠垂体LH的浓度显著低于正常雄性大鼠。去势后，下丘脑LHRH的含量最初下降，但从第17天起，新生期去势大鼠下丘脑LHRH的水平显著高于完整对照组。下丘脑LHRH含量最初的下降可能是由于LHRH释放的刺激超过了最大合成速率，而随后下丘脑LHRH含量的增加可能是去势导致LHRH合成增强的结果。
