Response of multiple demand network to visual search demands.

Neuroimaging studies for human participants have shown that the activity in the multiple-demand (MD) network is associated with various kinds of cognitive demand. However, surprisingly, it remains unclear how this MD network is related to a core component of cognition, the process of searching for a target among distractors. This was because previous neuroimaging studies of visual search were confounded by task difficulty or time on task. To circumvent these limitations, we examined human brain activity while participants perform two different visual search tasks. The performance of a task was limited by increased attentional demand, while the other task was primarily limited by poor quality of input data or neural noise. Throughout the MD network, increased activity and strengthened functional connectivity among the MD regions were observed under the search task recruiting capacity-limited attentional resources. The present findings provide unequivocal evidence that the MD network mediates visual search, as well as other capacity-limited cognitive processes.