KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
Wiad Lek. 2020;73(11):2411-2415.
The aim of this study was to investigate the relation between urinary TGF-β1, urinary VEGF and renal scarring resulted from VUR.
Materials and methods: This study included 141 patients with VUR and 34 healthy sex and age matched children. The statistical analysis consisted of descriptive statistical parameters, KruskalWallis, Mann-Whitney tests and ROC analysis.
Results: The urine levels of TGF-β1 and VEGF were significantly increased in children with VUR, compared to the controls. The levels of TGF-β1 urine excretion in children with renal scarring were higher compared children no renal scarring. The indicators of VEGF urine excretion in children with renal scarring compared to indicators in children no renal scarring, were lower, however exceeded the indicators in children of control group. The area under the ROC curve for TGF-β1 was 109.9, for VEGF was 207.6.
Conclusions: The study allowed to substantiate and propose non-invasive methods for early diagnosis of renal scarring in children with VUR.
本研究旨在探讨尿转化生长因子-β1（TGF-β1）、血管内皮生长因子（VEGF）与反流性肾病（VUR）所致肾瘢痕之间的关系。
本研究纳入 141 例 VUR 患儿和 34 名性别和年龄匹配的健康儿童。统计分析包括描述性统计参数、Kruskal-Wallis、Mann-Whitney 检验和 ROC 分析。
与对照组相比，VUR 患儿尿 TGF-β1 和 VEGF 水平显著升高。有肾瘢痕的患儿尿 TGF-β1 排泄量高于无肾瘢痕的患儿。有肾瘢痕的患儿 VEGF 尿排泄指标较无肾瘢痕的患儿低，但高于对照组患儿。TGF-β1 的 ROC 曲线下面积为 109.9，VEGF 的 ROC 曲线下面积为 207.6。
本研究证实并提出了用于早期诊断 VUR 患儿肾瘢痕的非侵入性方法。
