Obstetrics and Gynaecology Department, Faculty of Medicine, Udayana University, Denpasar-Bali, Indonesia.
Bali Royal Hospital, Royal IVF Clinic, Denpasar-Bali, Indonesia.
Zygote. 2021 Jun;29(3):229-233. doi: 10.1017/S0967199420000830. Epub 2021 Jan 18.
Polycystic ovary syndrome (PCOS) is a condition that affects fertility. There are two types of PCOS; the normal/lean type and overweight/obese type. The aim of this study was to assess baseline characteristics, ovarian response, quality of oocytes, embryos, pregnancy, implantation and live birth rates in normal/lean and overweight/obese patients with PCOS undergoing ICSI compared with patients without PCOS. This retrospective case-control analytical study included 38 normal/lean and 17 overweight/obese patients with PCOS, and 98 normal/lean and 17 overweight/obese patients without PCOS. Parameters were observed based on baseline characteristics, ovarian response to dosage and duration of gonadotropin administered, number of oocytes, matured oocytes, fertilization rate, embryo quality and development, pregnancy, implantation and live birth rates. Basal serum luteinizing hormone in normal/lean PCOS was significantly higher compared with non-PCOS groups. Total dosage of gonadotropin used was significantly lower in normal/lean PCOS compared with other groups. End estradiol levels in normal/lean PCOS was significantly higher compared with the non-PCOS groups. Number of follicles, retrieved oocytes and matured oocytes were significantly higher in PCOS groups compared with the non-PCOS groups. However, there were no differences in fertilized oocytes, cleavage, number of top-quality embryos, pregnancy, implantation, and live birth rates among groups. This present study suggests that normal/lean PCOS requires lower gonadotropin dosages and that patients with PCOS have more follicles and oocytes compared with patients without PCOS, however the number of fertilized oocytes and embryos from patients with PCOS were the same as those from patients without PCOS and suggested that the quality of retrieved oocytes in PCOS might be compromised.
多囊卵巢综合征（PCOS）是一种影响生育能力的疾病。PCOS 有两种类型；正常/消瘦型和超重/肥胖型。本研究旨在评估接受 ICSI 的 PCOS 正常/消瘦型和超重/肥胖型患者与非 PCOS 患者的基线特征、卵巢反应、卵子、胚胎、妊娠、着床和活产率。这项回顾性病例对照分析研究包括 38 名正常/消瘦型和 17 名超重/肥胖型 PCOS 患者，以及 98 名正常/消瘦型和 17 名超重/肥胖型非 PCOS 患者。观察的参数基于基线特征、卵巢对给予的促性腺激素剂量和持续时间的反应、卵子数量、成熟卵子、受精率、胚胎质量和发育、妊娠、着床和活产率。正常/消瘦型 PCOS 患者的基础血清黄体生成素明显高于非 PCOS 组。与其他组相比，正常/消瘦型 PCOS 患者使用的促性腺激素总剂量明显较低。正常/消瘦型 PCOS 的终末雌二醇水平明显高于非 PCOS 组。与非 PCOS 组相比，PCOS 组的卵泡数、取卵数和成熟卵数明显较高。然而，各组之间受精卵、卵裂、优质胚胎数、妊娠、着床和活产率没有差异。本研究表明，正常/消瘦型 PCOS 需要较低剂量的促性腺激素，与非 PCOS 患者相比，PCOS 患者的卵泡和卵子数量更多，但 PCOS 患者的受精卵和胚胎数量与非 PCOS 患者相同，这表明 PCOS 患者的取卵质量可能受损。
