Severance Emily G, Yolken Robert H
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Handb Behav Neurosci. 2016;23:501-516. doi: 10.1016/B978-0-12-800981-9.00029-8. Epub 2015 Nov 10.
In this chapter, we review data in support of the concept that immune system dysregulation is the most plausible explanation that reconciles gene by environmental interactions in schizophrenia. Early investigations of this topic demonstrated aspects of aberrant activation of humoral immunity, including autoimmunity, associated with schizophrenia, whereas current research efforts have expanded this theme to include elements of innate immunity. Advances in our understanding of inflammation and molecules of both the adaptive and innate immune system and their functional roles in standard brain physiology provide an important context by which schizophrenia might arise as the result of the coupling of immune and neurodevelopmental dysregulation.
在本章中，我们回顾了相关数据，以支持免疫系统失调是解释精神分裂症中基因与环境相互作用的最合理原因这一观点。对该主题的早期研究表明，体液免疫异常激活的各个方面，包括自身免疫，都与精神分裂症有关，而目前的研究工作已将这一主题扩展到包括先天免疫的要素。我们对炎症以及适应性和先天免疫系统的分子及其在标准脑生理学中的功能作用的理解取得了进展，这为精神分裂症可能作为免疫和神经发育失调耦合的结果而出现提供了重要背景。
