通过电子显微镜数据的傅里叶变换评估核小体在pBR322上的优先定位。
Preferential positioning of nucleosomes on pBR322 as evaluated via Fourier transform of data from electron microscopy.
作者信息
Caffarelli E, De Santis P, Leoni L, Palleschi A, Savino M
机构信息
Centro di Studio per gli Acidi Nucleici del Consiglio Nazionale delle Ricerche, Roma, Italy.
出版信息
Eur J Biochem. 1988 Feb 1;171(3):497-501. doi: 10.1111/j.1432-1033.1988.tb13817.x.
Abstract
Nucleosome positioning on pBR322 DNA has been evaluated by electron microscopy visualization, after psoralen cross-linking. The distribution function of nucleosomes on pBR322 DNA has been calculated analyzing the data of the electron microscopy via Fourier transform. This function shows definite maxima, which indicate differential interactions of the histone octamer to different DNA sequences.
摘要
在补骨脂素交联后，通过电子显微镜可视化评估了核小体在pBR322 DNA上的定位。通过傅里叶变换分析电子显微镜数据，计算了pBR322 DNA上核小体的分布函数。该函数显示出明确的最大值，这表明组蛋白八聚体与不同DNA序列存在差异相互作用。
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