抗细小病毒 B19 血清阴性的实体器官移植受者的细小病毒 B19 感染发生率和影响。
Incidence and Impact of Parvovirus B19 Infection in Seronegative Solid Organ Transplant Recipients.
机构信息
Viro-immunology Research Unit, Department of Infectious Diseases 8632, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Centre of Excellence for Health, Immunity, and Infections, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
出版信息
J Infect Dis. 2021 Sep 1;224(5):865-869. doi: 10.1093/infdis/jiab024.
Routine monitoring of parvovirus B19 (B19V) the first 6 months posttransplantation was performed in 241 seronegative solid organ transplant (SOT) recipients. Incidence rates during the first month and the second to sixth months posttransplantation were 1.2 (95% confidence interval [CI], .33-3.2) and 0.21 (95% CI, .06-.57) per 100 recipients per month, respectively. Of the 6 SOT recipients with positive B19V polymerase chain reaction, 3 (50%) were admitted to hospital and 2 (33%) were treated with intravenous immunoglobulin. Thus, routine monitoring of B19V in seronegative SOT recipients may not be necessary. Targeted screening 1 month posttransplantation and screening upon clinical suspicion could be an alternative strategy.
对 241 例血清阴性的实体器官移植（SOT）受者进行了移植后前 6 个月的细小病毒 B19（B19V）常规监测。移植后第一个月和第二个月至第六个月的发病率分别为每 100 名受者每月 1.2（95%置信区间 [CI]，0.33-3.2）和 0.21（95%CI，0.06-0.57）。在 6 例 B19V 聚合酶链反应阳性的 SOT 受者中，有 3 例（50%）住院，2 例（33%）接受了静脉注射免疫球蛋白治疗。因此，对血清阴性的 SOT 受者进行 B19V 的常规监测可能没有必要。在移植后 1 个月进行靶向筛查和在出现临床症状时进行筛查可能是一种替代策略。
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