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From functions to mechanisms of the prototypic complement C5 antibody BB5.1.
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Eculizumab-C5 complexes express a C5a neoepitope in vivo: Consequences for interpretation of patient complement analyses.
Mol Immunol. 2017 Sep;89:111-114. doi: 10.1016/j.molimm.2017.05.021. Epub 2017 Jun 10.
4
Current and future pharmacologic complement inhibitors.
Hematol Oncol Clin North Am. 2015 Jun;29(3):561-82. doi: 10.1016/j.hoc.2015.01.009. Epub 2015 Apr 4.
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[C5: eculizumab].
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Structural Basis for Eculizumab-Mediated Inhibition of the Complement Terminal Pathway.
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Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn.
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9
Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation.
Blood. 2017 Feb 23;129(8):970-980. doi: 10.1182/blood-2016-08-732800. Epub 2016 Dec 27.
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[Eculizumab in paroxysmal nocturnal hemoglobinuria].
Med Sci (Paris). 2009 Dec;25(12):1126-9. doi: 10.1051/medsci/200925121126.

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2
Complement, infection, and autoimmunity.
Curr Opin Rheumatol. 2019 Sep;31(5):532-541. doi: 10.1097/BOR.0000000000000633.
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The essential role of complement in antibody-mediated resistance to Salmonella.
Immunology. 2019 Jan;156(1):69-73. doi: 10.1111/imm.13000. Epub 2018 Oct 10.
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C5a induces caspase-dependent apoptosis in brain vascular endothelial cells in experimental lupus.
Immunology. 2016 Aug;148(4):407-19. doi: 10.1111/imm.12619. Epub 2016 Jul 11.
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Systemic and local anti-C5 therapy reduces the disease severity in experimental autoimmune uveoretinitis.
Clin Exp Immunol. 2010 Mar;159(3):303-14. doi: 10.1111/j.1365-2249.2009.04070.x. Epub 2009 Dec 4.

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