Milling Simon
Institute of Immunity, Infection, and Inflammation, University of Glasgow, Glasgow, UK.
Immunology. 2020 Oct;161(2):81-82. doi: 10.1111/imm.13261.
Antibodies that bind complement components were first identified over 30 years ago. Investigations into their functions in animal models motivated clinical studies that have now generated licensed products and a strong pipeline of future therapeutics. Despite this, the mechanisms of action of one of the first effective C5-binding antibodies, BB5.1, were not known. Here, we report a new study that reveals these mechanisms, enabling new approaches for designing C5-binding molecules for therapeutic use.
30多年前首次发现了能结合补体成分的抗体。对其在动物模型中功能的研究推动了临床研究,目前已产生了获批产品和一系列强大的未来治疗药物。尽管如此,首个有效的C5结合抗体BB5.1的作用机制仍不清楚。在此,我们报告一项新研究,揭示了这些机制,为设计用于治疗的C5结合分子提供了新方法。