腺嘌呤和3-脱氮腺嘌呤的9-（反式-2'，反式-3'-二羟基环戊-4'-烯基）衍生物：牛肝S-腺苷同型半胱氨酸水解酶的强效抑制剂。 - Suppr

Suppr

超能文献

9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl) derivatives of adenine and 3-deazaadenine: potent inhibitors of bovine liver S-adenosylhomocysteine hydrolase.

作者信息

Narayanan S R, Keller B T, Borcherding D R, Scholtz S A, Borchardt R T

机构信息

Department of Pharmaceutical Chemistry, University of Kansas, Lawrence 66045.

出版信息

J Med Chem. 1988 Mar;31(3):500-3. doi: 10.1021/jm00398a002.

DOI:10.1021/jm00398a002

PMID:3346868

Abstract

摘要

相似文献

9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl) derivatives of adenine and 3-deazaadenine: potent inhibitors of bovine liver S-adenosylhomocysteine hydrolase.腺嘌呤和3-脱氮腺嘌呤的9-（反式-2'，反式-3'-二羟基环戊-4'-烯基）衍生物：牛肝S-腺苷同型半胱氨酸水解酶的强效抑制剂。

J Med Chem. 1988 Mar;31(3):500-3. doi: 10.1021/jm00398a002.

Effects of 9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl)-adenine and -3-deazaadenine on the metabolism of S-adenosylhomocysteine in mouse L929 cells.9-（反式-2'，反式-3'-二羟基环戊-4'-烯基）腺嘌呤和-3-脱氮腺嘌呤对小鼠L929细胞中S-腺苷同型半胱氨酸代谢的影响。

Mol Pharmacol. 1988 Jun;33(6):713-20.

Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 11. Molecular dissections of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase.S-腺苷甲硫氨酸依赖性甲基转移酶的潜在抑制剂。11. 作为S-腺苷同型半胱氨酸水解酶潜在抑制剂的奈拉滨A的分子剖析。

J Med Chem. 1988 Sep;31(9):1729-38. doi: 10.1021/jm00117a011.

Inactivation of liver S-adenosylhomocysteine hydrolase in vitro of rats treated with erythro-9-(2-hydroxynon-3-yl)adenine.用赤藓红-9-(2-羟基壬-3-基)腺嘌呤处理的大鼠肝脏S-腺苷同型半胱氨酸水解酶的体外失活

Biochem J. 1982 Sep 1;205(3):585-92. doi: 10.1042/bj2050585.

Irreversible inhibition of S-adenosylhomocysteine hydrolase by nucleoside analogs.核苷类似物对S-腺苷同型半胱氨酸水解酶的不可逆抑制作用。

Arch Biochem Biophys. 1981 Mar;207(1):175-84. doi: 10.1016/0003-9861(81)90023-0.

Elucidation of the mechanism by which homocysteine potentiates the anti-vaccinia virus effects of the S-adenosylhomocysteine hydrolase inhibitor 9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl)-adenine.阐明同型半胱氨酸增强S-腺苷同型半胱氨酸水解酶抑制剂9-(反式-2',反式-3'-二羟基环戊-4'-烯基)-腺嘌呤抗痘苗病毒作用的机制。

Mol Pharmacol. 1989 Sep;36(3):490-6.

Synthesis of halogenated 9-(dihydroxycyclopent-4'-enyl) adenines and their inhibitory activities against S-adenosylhomocysteine hydrolase.卤代9-(二羟基环戊-4'-烯基)腺嘌呤的合成及其对S-腺苷同型半胱氨酸水解酶的抑制活性。

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):919-21. doi: 10.1081/NCN-120022686.

Activity of several S-adenosylhomocysteine hydrolase inhibitors against African swine fever virus replication in Vero cells.

Antiviral Res. 1993 Feb;20(2):131-44. doi: 10.1016/0166-3542(93)90003-2.

Adenine nucleoside dialdehydes: potent inhibitors of bovine liver S-adenosylhomocysteine hydrolase.腺嘌呤核苷二醛：牛肝S-腺苷同型半胱氨酸水解酶的强效抑制剂。

Biochemistry. 1985 Feb 26;24(5):1130-6. doi: 10.1021/bi00326a010.

Antiviral potency of adenosine analogues: correlation with inhibition of S-adenosylhomocysteine hydrolase.腺苷类似物的抗病毒效力：与S-腺苷同型半胱氨酸水解酶抑制作用的相关性。

Biochem Biophys Res Commun. 1985 May 31;129(1):306-11. doi: 10.1016/0006-291x(85)91438-x.

引用本文的文献

Relationship between intracellular concentration of S-adenosylhomocysteine and inhibition of vaccinia virus replication and inhibition of murine L-929 cell growth.S-腺苷同型半胱氨酸细胞内浓度与牛痘病毒复制抑制及小鼠L-929细胞生长抑制之间的关系

Antimicrob Agents Chemother. 1989 Jun;33(6):828-34. doi: 10.1128/AAC.33.6.828.

Broad-spectrum antiviral activities of neplanocin A, 3-deazaneplanocin A, and their 5'-nor derivatives.奈普拉诺辛A、3-去氮奈普拉诺辛A及其5'-去甲衍生物的广谱抗病毒活性。

Antimicrob Agents Chemother. 1989 Aug;33(8):1291-7. doi: 10.1128/AAC.33.8.1291.

A molecular model for the active site of S-adenosyl-L-homocysteine hydrolase.S-腺苷-L-高半胱氨酸水解酶活性位点的分子模型。

J Comput Aided Mol Des. 1991 Jun;5(3):213-34. doi: 10.1007/BF00124340.

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