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基底动脉闭塞及新兴治疗方法。

Basilar Artery Occlusion and Emerging Treatments.

机构信息

Department of Neurology and UCLA Stroke Center, University of California, Los Angeles, Los Angeles, California.

Neurovascular Imaging Research Core, University of California, Los Angeles, Los Angeles, California.

出版信息

Semin Neurol. 2021 Feb;41(1):39-45. doi: 10.1055/s-0040-1722638. Epub 2021 Jan 14.

Abstract

Basilar artery occlusion is a relatively uncommon but neurologically devastating condition. If revascularization is not achieved, the potential for death and disability is substantial. During the last several years, there have been positive endovascular stroke trials for the treatment of large vessel occlusion; however, all of them excluded patients with basilar artery occlusion. The current treatment of basilar artery occlusion is still founded on small observational studies or meta-analyses. As case selection for revascularization and treatment protocols often vary widely across institutions, sample sizes remain limited. In this article, we aim to review some of the larger observational studies in stroke due to basilar artery occlusion, considering potential treatment strategies and resultant outcomes.

摘要

基底动脉闭塞是一种相对少见但神经功能破坏性很强的疾病。如果不能实现再通,患者死亡和残疾的风险非常高。在过去几年中,有一些积极的血管内卒中临床试验针对大血管闭塞进行治疗;然而,所有这些试验都排除了基底动脉闭塞的患者。目前,基底动脉闭塞的治疗仍然基于小型观察性研究或荟萃分析。由于再通和治疗方案的病例选择在不同机构之间差异很大,因此样本量仍然有限。在本文中,我们旨在回顾一些较大的基底动脉闭塞性卒中的观察性研究,考虑潜在的治疗策略和结果。

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