Flukes Stephanie, Long Sallie, Lohia Shivangi, Barker Christopher A, Dunn Lara A, Cracchiolo Jennifer, Ganly Ian, Patel Snehal, Cohen Marc A
Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Department of Otolaryngology-Head and Neck Surgery, New York-Presbyterian Hospital Weill Cornell Medicine, New York, New York, USA.
OTO Open. 2021 Jan 8;5(1):2473974X20984720. doi: 10.1177/2473974X20984720. eCollection 2021 Jan-Mar.
To characterize a subset of patients with metastatic head and neck cutaneous squamous cell carcinoma in a tertiary North American center and describe oncologic outcomes following definitive treatment.
Retrospective chart review.
National Cancer Institute-designated Comprehensive Cancer Center.
We conducted a retrospective chart review of patients with cutaneous squamous cell carcinoma with metastases to intraparotid lymph nodes who underwent parotidectomy between 1993 and 2020. Baseline patient and tumor characteristics were assessed. Regional control, disease-specific survival, and overall survival were estimated using Kaplan-Meier method. Multivariate analysis was used to determine the relationship between adverse pathological features and survival.
A total of 122 patients were included. The median age was 76, 84.4% of patients were male, and 17.2% were immunosuppressed. Regional control, disease-specific survival, and overall survival were 68.5%, 70.7%, and 59.4% at 5 years, respectively. Perineural and lymphovascular invasion were predictive of worse disease-specific survival. Extracapsular spread was observed in 90.2% of patients and was not a significant predictor of outcome.
We found the demographics and oncologic outcomes of our cohort in the Northeast United States to be comparable with those previously reported in Australia and the Sun Belt of the United States. We noted a high rate of extracapsular spread but did not find it to be a significant predictor of recurrence or survival. Future efforts should address the impact of extracapsular spread on prognosis and adjuvant treatment decisions.
在北美一家三级医疗中心对转移性头颈部皮肤鳞状细胞癌患者的一个亚组进行特征描述，并描述确定性治疗后的肿瘤学结局。
回顾性病历审查。
美国国立癌症研究所指定的综合癌症中心。
我们对1993年至2020年间接受腮腺切除术的腮腺内淋巴结转移的皮肤鳞状细胞癌患者进行了回顾性病历审查。评估了患者和肿瘤的基线特征。使用Kaplan-Meier方法估计区域控制率、疾病特异性生存率和总生存率。采用多变量分析确定不良病理特征与生存率之间的关系。
共纳入122例患者。中位年龄为76岁，84.4%的患者为男性，17.2%的患者免疫功能低下。5年时的区域控制率、疾病特异性生存率和总生存率分别为68.5%、70.7%和59.4%。神经周围和淋巴管侵犯预示着更差的疾病特异性生存率。90.2%的患者观察到包膜外扩散，且它不是结局的显著预测因素。
我们发现美国东北部我们队列的人口统计学和肿瘤学结局与澳大利亚和美国阳光地带先前报道的结果相当。我们注意到包膜外扩散率很高，但未发现它是复发或生存的显著预测因素。未来的工作应关注包膜外扩散对预后和辅助治疗决策的影响。
