Lee Jong Soo, Lee Min Ho, Kim Jae Hyun, Jo Yeon Ji, Shin Jong Hun, Park Hyun Jun
Department of Ophthalmology, Pusan National University College of Medicine & Medical Research Institute of Pusan National University Hospital, Busan, Korea.
Busan BalGeunSeSang Eye Clinic, Busan, Korea.
World J Mens Health. 2021 Oct;39(4):697-704. doi: 10.5534/wjmh.200066. Epub 2020 Sep 17.
To investigate the association between intraocular pressure (IOP) and serum testosterone according to the severity of obesity.
We investigated the correlation of IOP-testosterone according to the anthropometric obesity indices, such as obesity index (OI), body mass index (BMI), and waist circumference to height ratio (WtHR). Each of the obesity indices was classified into three groups: normal, overweight, and obesity. In additional, the association of IOP-testosterone was compared between testosterone 3.0 ng/mL below and above.
Total of 3,949 participants, the mean age was 58.86±10.06 years, mean IOP was 14.40±2.61 mmHg, mean arterial blood pressure (MAP) was 93.67±11.47 mmHg, and mean serum testosterone was 4.21±1.83 ng/mL. The association of MAP and IOP was significantly positively correlated according to the severity of obesity, but testosterone showed a significant negative relationship (p<0.05). IOP was significantly correlated with OI and BMI, but MAP and testosterone were correlated with all anthropometric obesity indices (p<0.05). The relationship of IOP and testosterone was significantly associated with only normal groups according to the degree of obesity (p<0.05). The IOP in patients with testosterone above 3.0 ng/mL was significantly higher than testosterone below 3.0 ng/mL (p<0.05).
The correlation of IOP-testosterone has a significantly positive relationship, in case of healthy men with normal weight by OI or BMI.
根据肥胖严重程度调查眼压（IOP）与血清睾酮之间的关联。
我们根据人体测量肥胖指数，如肥胖指数（OI）、体重指数（BMI）和腰围身高比（WtHR），研究眼压与睾酮的相关性。每个肥胖指数分为三组：正常、超重和肥胖。此外，比较了睾酮低于3.0 ng/mL和高于3.0 ng/mL时眼压与睾酮的关联。
共有3949名参与者，平均年龄为58.86±10.06岁，平均眼压为14.40±2.61 mmHg，平均动脉血压（MAP）为93.67±11.47 mmHg，平均血清睾酮为4.21±1.83 ng/mL。根据肥胖严重程度，MAP与IOP的关联呈显著正相关，但睾酮呈显著负相关（p<0.05）。IOP与OI和BMI显著相关，但MAP和睾酮与所有人体测量肥胖指数相关（p<0.05）。根据肥胖程度，IOP与睾酮的关系仅在正常组中显著相关（p<0.05）。睾酮高于3.0 ng/mL患者的IOP显著高于睾酮低于3.0 ng/mL的患者（p<0.05）。
对于通过OI或BMI判断体重正常的健康男性，IOP与睾酮的相关性呈显著正相关。
