血管活性肠肽是假定的控制大鼠泪腺蛋白质分泌的非胆碱能、非肾上腺素能神经递质吗？

Is VIP the putative non-cholinergic, non-adrenergic neurotransmitter controlling protein secretion in rat lacrimal glands?

作者信息

Hussain M, Singh J

机构信息

School of Applied Biology, Lancashire Polytechnic, Preston.

出版信息

Q J Exp Physiol. 1988 Jan;73(1):135-8. doi: 10.1113/expphysiol.1988.sp003112.

DOI:10.1113/expphysiol.1988.sp003112

PMID:3347693

Abstract

In the combined presence of cholinergic and adrenergic antagonists, electrical field stimulation (FS) caused a marked reversible increase in protein output from superfused rat lacrimal gland segments. The FS-evoked protein output was abolished by the nerve blocking drug tetrodotoxin (TTX; 10(-6) M) whereas high potassium (K+; 100 mM) continued to elicit secretion. Vasoactive intestinal polypeptide (VIP), but not adenosine 5'-triphosphate (ATP), stimulated protein secretion in a manner almost identical to that observed in response to FS. The results suggest that the non-cholinergic, non-adrenergic secretory response may involve VIP as an endogenous neurotransmitter.

摘要

在胆碱能和肾上腺素能拮抗剂同时存在的情况下，电场刺激（FS）可使灌流大鼠泪腺段的蛋白质分泌显著且可逆地增加。神经阻断药物河豚毒素（TTX；10⁻⁶ M）可消除FS诱发的蛋白质分泌，而高钾（K⁺；100 mM）仍能引发分泌。血管活性肠肽（VIP）而非三磷酸腺苷（ATP）以与FS刺激几乎相同的方式刺激蛋白质分泌。结果表明，非胆碱能、非肾上腺素能分泌反应可能涉及VIP作为内源性神经递质。