多中心队列研究中肝移植后新发实体瘤和血液系统恶性肿瘤的累积发生率。

Cumulative incidence of solid and hematological De novo malignancy after liver transplantation in a multicentre cohort.

机构信息

Gastroenterology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Catholic University of the Sacred Heart, Rome, Italy.

出版信息

Ann Hepatol. 2021 Sep-Oct;24:100309. doi: 10.1016/j.aohep.2021.100309. Epub 2021 Jan 20.

DOI:10.1016/j.aohep.2021.100309

PMID:33482364

Abstract

BACKGROUND

Recent innovations in the field of liver transplantation have led to a wealth of new treatment regimes, with potential impact on the onset of de novo malignancies (DNM). The aim of this multicenter cohort study was to provide contemporary figures for the cumulative incidences of solid and hematological DNM after liver transplantation.

METHODS

We designed a retrospective cohort study including patients undergoing LT between 2000 and 2015 in three Italian transplant centers. Cumulative incidence was calculated by Kaplan-Meyer analysis.

RESULTS

The study included 789 LT patients with a median follow-up of 81 months (IQR: 38-124). The cumulative incidence of non-cutaneous DNM was 6.2% at 5-years, 11.6% at 10-years and 16.3% at 15-years. Post-Transplant Lymphoproliferative Disorders (PTLD) were demonstrated to have a cumulative incidence of 1.0% at 5-years, 1.6% at 10-years and 2.2% at 15-years. Solid Organ Tumors (SOT) demonstrated higher cumulative incidences - 5.3% at 5-years, 10.3% at 10-years and 14.4% at 15-years. The most frequently observed classifications of SOT were lung (rate 1.0% at 5-years, 2.5% at 10-years) and head & neck tumors (rate 1.3% at 5-years, 1.9% at 10-years).

CONCLUSIONS

Lung tumors and head & neck tumors are the most frequently observed SOT after LT.

摘要

背景

肝脏移植领域的最新创新带来了丰富的新治疗方案，可能会影响新发恶性肿瘤（DNM）的发生。本多中心队列研究旨在提供肝移植后实体瘤和血液系统 DNM 累积发生率的当代数据。

方法

我们设计了一项回顾性队列研究，纳入了 2000 年至 2015 年在意大利三个移植中心接受 LT 的患者。通过 Kaplan-Meier 分析计算累积发生率。

结果

该研究纳入了 789 例 LT 患者，中位随访时间为 81 个月（IQR：38-124）。5 年、10 年和 15 年时非皮肤 DNM 的累积发生率分别为 6.2%、11.6%和 16.3%。PTLD 的累积发生率为 5 年时为 1.0%，10 年时为 1.6%，15 年时为 2.2%。实体器官肿瘤（SOT）的累积发生率更高 - 5 年时为 5.3%，10 年时为 10.3%，15 年时为 14.4%。最常观察到的 SOT 分类为肺部（5 年时为 1.0%，10 年时为 2.5%）和头颈部肿瘤（5 年时为 1.3%，10 年时为 1.9%）。