人乳中的阿昔洛韦。

Acyclovir in human breast milk.

作者信息

Meyer L J, de Miranda P, Sheth N, Spruance S

机构信息

Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City.

出版信息

Am J Obstet Gynecol. 1988 Mar;158(3 Pt 1):586-8. doi: 10.1016/0002-9378(88)90033-6.

DOI:10.1016/0002-9378(88)90033-6

PMID:3348321

Abstract

Acyclovir concentration was measured by radioimmunoassay in the serum and milk of a lactating woman who was treated with oral acyclovir for herpes zoster. Daily serum and milk samples showing milk concentrations that averaged being 3.24-fold higher than serum levels suggest a low infant dose. The elimination phase demonstrated a half-life of 2.8 hours in milk.

摘要

采用放射免疫分析法测定了一名口服阿昔洛韦治疗带状疱疹的哺乳期妇女血清和乳汁中的阿昔洛韦浓度。每日采集的血清和乳汁样本显示，乳汁中的阿昔洛韦浓度平均比血清水平高3.24倍，提示婴儿摄入剂量较低。消除阶段显示，乳汁中的半衰期为2.8小时。