Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Stem Cell and Regenerative Medicine Institute, Samsung Medical Center, Seoul, South Korea.
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Stem Cell and Regenerative Medicine Institute, Samsung Medical Center, Seoul, South Korea; Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, South Korea.
Pediatr Neonatol. 2021 Feb;62 Suppl 1:S16-S21. doi: 10.1016/j.pedneo.2020.11.007. Epub 2020 Dec 4.
Mesenchymal stem cell (MSC) transplantation has emerged as a new promising therapeutic strategy for the treatment of intractable and devastating neonatal disorders with complex multifactorial etiologies, including bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH), and hypoxic-ischemic encephalopathy (HIE). In response to inflammatory and noxious environments, MSCs secrete various paracrine factors that perform several reparative functions, including exerting anti-inflammatory, anti-oxidative, anti-apoptotic, and anti-fibrotic effects, to enhance the regeneration of damaged cells and tissues. In this review, we summarize recent advances in stem cell research focusing on the use of MSCs in the prevention and treatment of newborn BPD, IVH and HIE, with particular emphasis on preclinical and clinical data.
间充质干细胞（MSC）移植已成为一种新的有前途的治疗策略，用于治疗具有复杂多因素病因的难治性和破坏性新生儿疾病，包括支气管肺发育不良（BPD）、脑室内出血（IVH）和缺氧缺血性脑病（HIE）。MSC 会在炎症和有害环境中分泌各种旁分泌因子，从而发挥多种修复功能，包括抗炎、抗氧化、抗凋亡和抗纤维化作用，以增强受损细胞和组织的再生。在这篇综述中，我们总结了干细胞研究的最新进展，重点介绍了 MSCs 在预防和治疗新生儿 BPD、IVH 和 HIE 中的应用，特别强调了临床前和临床数据。
