Taga Yukiko, Chigusa Yoshitsugu, Minamiguchi Sachiko, Kido Aki, Horikawa Naoki, Horie Akihito, Hamanishi Junzo, Kondoh Eiji, Mandai Masaki, Yamaguchi Ken
Department of Gynecology and Obstetrics, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507 Japan.
Department of Diagnostic Pathology, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507 Japan.
Int Cancer Conf J. 2020 Sep 21;10(1):46-53. doi: 10.1007/s13691-020-00447-x. eCollection 2021 Jan.
Ovarian seromucinous carcinoma (SMC) is an uncommon neoplasia and is composed predominantly of serous and endocervical-type mucinous epithelium. Due to its low frequency and difficult diagnosis, the natural history, characteristic imaging findings, and pathological features of SMC have not been adequately described in the literature thus far. We herein report three cases of ovarian SMC along with magnetic resonance imaging (MRI) findings. The diagnosis of SMC was made after staging laparotomy in all cases, and systemic chemotherapy was performed in two cases. No recurrence was observed in any of the cases. The MRI findings in SMC were so varied that characteristic imaging features useful for diagnosis were not found. In two cases, MRI suggested endometriotic cysts, and endometriosis and seromucinous borderline tumors (SMBTs) were detected concurrently in all cases by histological examination. Thus, it was suggested that SMC develops in multiple stages via endometriosis and SMBT. The cooccurrence of endometriosis and SMBT could also make the diagnosis of SMC more convincing.
卵巢浆液黏液性癌（SMC）是一种罕见的肿瘤，主要由浆液性和宫颈内膜样黏液上皮组成。由于其发病率低且诊断困难，迄今为止，SMC的自然病史、特征性影像学表现和病理特征在文献中尚未得到充分描述。我们在此报告3例卵巢SMC及其磁共振成像（MRI）表现。所有病例均在分期剖腹手术后确诊为SMC，2例接受了全身化疗。所有病例均未观察到复发。SMC的MRI表现多种多样，未发现有助于诊断的特征性影像学特征。2例MRI提示为子宫内膜异位囊肿，组织学检查在所有病例中均同时检测到子宫内膜异位症和浆液黏液性交界性肿瘤（SMBT）。因此，提示SMC通过子宫内膜异位症和SMBT多阶段发展。子宫内膜异位症和SMBT的同时存在也可能使SMC的诊断更具说服力。
