Ha Albert S, Chung Rainjade, Thorogood Samantha, Weiner David M, Shah Ojas, Healy Kelly A
Department of Urology, Columbia University Irving Medical Center, New York, NY, USA.
Department of Urology, Weill Cornell Medicine, New York, NY, USA.
Urol Case Rep. 2021 Jan 8;36:101563. doi: 10.1016/j.eucr.2021.101563. eCollection 2021 May.
Hypercalcemia and nephrolithiasis have been associated with various etiologies, including dysregulation of the parathyroid glands, malignancies, or sarcoidosis. Other causes of hypercalcemia, such as granulomatous disease resulting from silicone-based cosmetic injections, have been reported but without specific emphasis on nephrolithiasis. Herein, we report an unusual case of simultaneous bilateral obstructing ureteral calculi (SBUC) triggered by recalcitrant hypercalcemia and granulomatous disease due to silicone-based cosmetic injections. A careful surgical history, physical exam, and imaging identified the underlying etiology, which was confirmed by final histopathology. Using a multidisciplinary approach, the patient's condition was successfully managed with endoscopic procedures and concurrent corticosteroid therapy.
高钙血症和肾结石与多种病因相关，包括甲状旁腺功能失调、恶性肿瘤或结节病。其他高钙血症的病因，如硅基美容注射导致的肉芽肿病，已有报道，但未特别强调肾结石。在此，我们报告一例罕见病例，由硅基美容注射引起的顽固性高钙血症和肉芽肿病引发双侧同时性输尿管结石梗阻（SBUC）。通过仔细询问手术史、体格检查和影像学检查确定了潜在病因，并经最终组织病理学证实。采用多学科方法，通过内镜手术和同时进行的皮质类固醇治疗成功控制了患者的病情。
