Department of Gynecological Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
Department of Gynecology and Obstetrics, Medical Faculty Ljubljana, Ljubljana, Slovenia.
Am J Case Rep. 2021 Jan 26;22:e928959. doi: 10.12659/AJCR.928959.
BACKGROUND Small cell ovarian carcinoma, hypercalcemic type is an uncommon malignant ovarian tumor entity with an unfavorable prognosis and a short overall survival rate. It mainly affects women of childbearing age. CASE REPORT We report a case in which a 31-year-old woman with small cell ovarian carcinoma, hypercalcemic type presented with unspecific symptoms. We emphasize the importance of treatment planning and address fertility-sparing surgical procedures, which remain a therapeutic dilemma. CONCLUSIONS The occurrence of unspecific abdominal symptoms, unilateral tumor masses, and hypercalcemia may indicate the presence of malignant ovarian neoplasm in young adults. Histopathological examination of the mass should be performed by an experienced gynecological pathologist. A misdiagnosis can lead to inadequate surgical and adjuvant treatment. Adjuvant multi-agent chemotherapy and high-dose chemotherapy with autologous stem cell rescue may prolong the progression-free interval and overall survival.
小细胞卵巢癌,高钙血症型是一种罕见的恶性卵巢肿瘤实体,预后不良,总生存率短。它主要影响育龄妇女。
我们报告了一例小细胞卵巢癌,高钙血症型的 31 岁女性患者,表现为非特异性症状。我们强调了治疗计划的重要性,并讨论了保留生育能力的手术程序,这仍然是一个治疗上的难题。
年轻成年人出现非特异性腹部症状、单侧肿瘤和高钙血症可能提示存在恶性卵巢肿瘤。应由经验丰富的妇科病理学家对肿块进行组织病理学检查。误诊可能导致手术和辅助治疗不足。辅助多药化疗和大剂量化疗联合自体干细胞解救可能延长无进展间期和总生存期。