Emerg Infect Dis. 2021 Feb;27(2):443-451. doi: 10.3201/eid2702.201945.
The incidence of invasive group A Streptococcus (iGAS) disease in the general population in Alberta, Canada, has been steadily increasing. To determine whether rates for specific populations such as First Nations are also increasing, we investigated iGAS cases among First Nations persons in Alberta during 2003-2017. We identified cases by isolating GAS from a sterile site and performing emm typing. We collected demographic, social, behavioral, and clinical data for patients. During the study period, 669 cases of iGAS in First Nations persons were reported. Incidence increased from 10.0 cases/100,000 persons in 2003 to 52.2 cases/100,000 persons in 2017. The 2017 rate was 6 times higher for the First Nations population than for non-First Nations populations (8.7 cases/100,000 persons). The 5 most common emm types from First Nations patients were 59, 101, 82, 41, and 11. These data indicate that iGAS is severely affecting the First Nations population in Alberta, Canada.
加拿大艾伯塔省普通人群中侵袭性 A 组链球菌（iGAS）疾病的发病率一直在稳步上升。为了确定特定人群（如第一民族）的发病率是否也在上升，我们调查了 2003 年至 2017 年期间艾伯塔省第一民族人群中的 iGAS 病例。我们通过从无菌部位分离 GAS 并进行 emm 分型来确定病例。我们为患者收集了人口统计学、社会、行为和临床数据。在研究期间，报告了 669 例第一民族人群中的 iGAS 病例。发病率从 2003 年的每 10 万人 10.0 例上升到 2017 年的每 10 万人 52.2 例。2017 年的发病率是第一民族人群的 6 倍，而非第一民族人群的 8.7 例/10 万人。来自第一民族患者的 5 种最常见的 emm 型是 59、101、82、41 和 11。这些数据表明，iGAS 严重影响了加拿大艾伯塔省的第一民族人群。
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